| Literature DB >> 11181391 |
S Zbaida1, J Brieland, P Krieter, D Loebenberg, G Krishna, D Horne, X Lu, Y Yuan, R Hare, M N Cayen, J E Patrick.
Abstract
The in vitro uptake of [(14)C]evernimicin ([(14)C]SCH 27899) by primary cultures of rat alveolar macrophages and hepatocytes was determined. Both cell populations exhibited linear rates of uptake. However, the initial rate of drug uptake by alveolar macrophages was about threefold higher than that by hepatocytes. These findings demonstrate that [(14)C]evernimicin is taken up by rat alveolar macrophages, supporting the likelihood that the drug is able to reach sites of infection.Entities:
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Year: 2001 PMID： 11181391 PMCID： PMC90404 DOI： 10.1128/AAC.45.3.959-961.2001
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191