Literature DB >> 11181374

Molecular and biochemical analysis of AST-1, a class A beta-lactamase from Nocardia asteroides sensu stricto.

L Poirel1, F Laurent, T Naas, R Labia, P Boiron, P Nordmann.   

Abstract

A beta-lactamase gene was cloned from a Nocardia asteroides sensu stricto clinical isolate. A recombinant plasmid, pAST-1, expressed the beta-lactamase AST-1 in Escherichia coli JM109. Its pI was 4.8, and its relative molecular mass was 31 kDa. E. coli JM109(pAST-1) was resistant to penicillins and narrow-spectrum cephalosporins. The beta-lactamase AST-1 had a restricted hydrolytic activity spectrum. Its activity was partially inhibited by clavulanic acid but not by sulbactam and tazobactam. AST-1 is an Ambler class A beta-lactamase sharing 65% amino acid identity with beta-lactamase FAR-1, the most closely related enzyme.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11181374      PMCID： PMC90387          DOI： 10.1128/AAC.45.3.878-882.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Nocardia and nocardiosis.

Authors:  B L Beaman; P Boiron; L Beaman; G H Brownell; K Schaal; M E Gombert
Journal:  J Med Vet Mycol       Date:  1992

2.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

3.  Acquired resistance of Nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid.

Authors:  V A Steingrube; R J Wallace; B A Brown; Y Pang; B Zeluff; L C Steele; Y Zhang
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

Review 4.  Nocardiosis.

Authors:  P I Lerner
Journal:  Clin Infect Dis       Date:  1996-06       Impact factor: 9.079

5.  Non-inducible, mainly cell-associated beta-lactamase from Nocardia asteroides strain 108.

Authors:  F Scopetti; L Fattorini; N Franceschini; G Amicosante; G Orefici
Journal:  J Antimicrob Chemother       Date:  1997-07       Impact factor: 5.790

6.  Partial characterization of Nocardia farcinica beta-lactamases.

Authors:  V A Steingrube; R J Wallace; B A Brown; Y Zhang; L C Steele; G Young; D R Nash
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

7.  Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.

Authors:  B Joris; P Ledent; O Dideberg; E Fonzé; J Lamotte-Brasseur; J A Kelly; J M Ghuysen; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

8.  DNA amplification and restriction endonuclease analysis for differentiation of 12 species and taxa of Nocardia, including recognition of four new taxa within the Nocardia asteroides complex.

Authors:  V A Steingrube; B A Brown; J L Gibson; R W Wilson; J Brown; Z Blacklock; K Jost; S Locke; R F Ulrich; R J Wallace
Journal:  J Clin Microbiol       Date:  1995-12       Impact factor: 5.948

9.  Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.

Authors:  C Cantu; W Huang; T Palzkill
Journal:  J Biol Chem       Date:  1996-09-13       Impact factor: 5.157

10.  Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans.

Authors:  J J Coque; P Liras; J F Martín
Journal:  EMBO J       Date:  1993-02       Impact factor: 11.598
View more
  6 in total

Review 1.  A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes.

Authors:  Alain Philippon; Patrick Slama; Paul Dény; Roger Labia
Journal:  Clin Microbiol Rev       Date:  2016-01       Impact factor: 26.132

2.  Chromosome-borne class A BOR-1 beta-Lactamase of Bordetella bronchiseptica and Bordetella parapertussis.

Authors:  Marie-Frédérique Lartigue; Laurent Poirel; Nicolas Fortineau; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

Review 3.  Beta-lactamase nomenclature.

Authors:  George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

4.  Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.

Authors:  Eric Sauvage; Eveline Fonzé; Birgit Quinting; Moreno Galleni; Jean-Marie Frère; Paulette Charlier
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

5.  The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases.

Authors:  Justin A McDonough; Kari E Hacker; Anthony R Flores; Martin S Pavelka; Miriam Braunstein
Journal:  J Bacteriol       Date:  2005-11       Impact factor: 3.490

6.  Resistance gene pool to co-trimoxazole in non-susceptible Nocardia strains.

Authors:  Sylvia Valdezate; Noelia Garrido; Gema Carrasco; Pilar Villalón; María J Medina-Pascual; Juan A Saéz-Nieto
Journal:  Front Microbiol       Date:  2015-04-28       Impact factor: 5.640
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.