| Literature DB >> 11181132 |
N P Juffermans1, P Speelman, A Verbon, J Veenstra, C Jie, S J van Deventer, T van Der Poll.
Abstract
Expression of human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5 was found to be elevated on CD4(+) T cells (1) in blood samples obtained from patients with tuberculosis and (2) in blood samples obtained from healthy subjects and stimulated with mycobacterial lipoarabinomannan in vitro. These data suggest that the increase in HIV viremia that occurs in association with tuberculosis may result from up-regulation of CXCR4 and CCR5 on CD4(+) T cells, thereby causing acceleration of HIV infection.Entities:
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Year: 2001 PMID: 11181132 DOI: 10.1086/318701
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079