| Literature DB >> 11179609 |
Z Arihara1, K Takahashi, O Murakami, K Totsune, M Sone, F Satoh, S Ito, T Mouri.
Abstract
Orexin-A and orexin-B are newly discovered neuropeptides which are implicated in feeding behavior and arousal state. We studied immunoreactive(IR)-orexin-A concentrations in human plasma by radioimmunoassay. IR-orexin-A concentrations in plasma obtained from 17 healthy subjects in the morning were 1.94 +/- 0.24 pmol/liter (mean +/- SEM). IR-orexin-A levels in the plasma obtained at night were not significantly different from those obtained in the morning in 9 female subjects. The HPLC analysis of the plasma extract showed two immunoreactive peaks; one peak eluting in an identical position to synthetic orexin-A, and one eluting earlier. This study has shown for the first time the presence of orexin-A in human plasma.Entities:
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Year: 2001 PMID： 11179609 DOI： 10.1016/s0196-9781(00)00369-7
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750