| Literature DB >> 11177387 |
L G Rivera-Morales1, V A Novitsky, J R Trujillo, C Lavalle-Montalvo, C Cano-Dominguez, J Ramos-Jimenez, E Jimenez-Rios, L Flores-Flores, P Lopez-Guillen, P Gilbert, F Vannberg, R Tamez-Guerra, C Rodriguez-Padilla, M Essex.
Abstract
Genotypic characteristics of human immunodeficiency virus type 1 (HIV-1) in Mexico were investigated in a multicenter study that involved centers in five geographic regions of the country. Study samples (n = 65) collected from male patients in 1998-1999 were sequenced within the C2-V5 region of the gp120 env gene. Phylogenetic analysis revealed that subtype B predominates in Mexico. The level of interpatient nucleotide diversity (mean value of 8.9%) was congruent with multiple introductions of the virus and the "aging" epidemic in Mexico. One-third of samples (30.8% of cases) showed polymorphism within the crown of the V3 loop demonstrating non-GPGR motifs. Two new motifs in the V3 loop crown - HPGG and GPEG - were observed. The evolution of the AIDS epidemic in Mexico should be closely monitored since non-B HIV-1 subtypes might be introduced. The nucleotide sequences were deposited in the GenBank under accession numbers AF200855-AF200869, AF200871-AF200892, and AF200894-AF200921.Entities:
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Year: 2001 PMID： 11177387 DOI： 10.1089/088922201750056825
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205