Literature DB >> 11177250

Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease.

V P Chekhonin1, V P Baklaushev, B M Kogan, E A Savchenko, S V Lebedev, I V Man'kovskaya, T S Filatova, I U Yusupova, T B Dmitrieva.   

Abstract

The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.

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Year:  2000        PMID： 11177250     DOI： 10.1007/bf02766101

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV.

Authors:  Julia S Seay; Roger McIntosh; Erin M Fekete; Mary Ann Fletcher; Mahendra Kumar; Neil Schneiderman; Michael H Antoni
Journal:  Psychoneuroendocrinology       Date:  2013-07-10       Impact factor: 4.905

2.  Urinary Neurotransmitter Patterns Are Altered in Canine Epilepsy.

Authors:  Teresa Schmidt; Sebastian Meller; Steven R Talbot; Benjamin A Berk; Tsz H Law; Sarah L Hobbs; Nina Meyerhoff; Rowena M A Packer; Holger A Volk
Journal:  Front Vet Sci       Date:  2022-05-16

3.  Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults.

Authors:  Mirjam Bloemendaal; Monja Isabel Froböse; Joost Wegman; Bram Bastiaan Zandbelt; Ondine van de Rest; Roshan Cools; Esther Aarts
Journal:  eNeuro       Date:  2018-04-30

4.  Urinary Aromatic Amino Acid Metabolites Associated With Postoperative Emergence Agitation in Paediatric Patients After General Anaesthesia: Urine Metabolomics Study.

Authors:  Yueyue Li; Jingjie Li; Yuhuan Shi; Xuhui Zhou; Wanqing Feng; Lu Han; Daqing Ma; Hong Jiang; Yongfang Yuan
Journal:  Front Pharmacol       Date:  2022-07-19       Impact factor: 5.988
  4 in total

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