Literature DB >> 11177232

Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals.

L V Loskutova1, N G Kolosova.   

Abstract

Comparative analysis of unconditioned and conditioned behavior of Wistar and prematurely aging OXYS rats revealed that the latter have significantly reduced locomotor and exploratory activities, increased anxiety in the elevated plus-maze test, spatial disorientation, and abnormal associative learning. OXYS rats can be used as a biological model for studying molecular, neurobiological, and neurochemical mechanisms of brain aging.

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Year:  2000        PMID： 11177232     DOI： 10.1007/bf02766083

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  Effect of malate on the development of rotenone-induced brain changes in Wistar and OXYS rats: An MRI study.

Authors:  N G Kolosova; A E Akulov; N A Stefanova; M P Moshkin; A A Savelov; I V Koptyug; A V Panov; V A Vavilin
Journal:  Dokl Biol Sci       Date:  2011-05-12

Review 2.  Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.

Authors:  Natalia A Stefanova; Oyuna S Kozhevnikova; Anton O Vitovtov; Kseniya Yi Maksimova; Sergey V Logvinov; Ekaterina A Rudnitskaya; Elena E Korbolina; Natalia A Muraleva; Nataliya G Kolosova
Journal:  Cell Cycle       Date:  2014-02-17       Impact factor: 4.534

3.  Rapamycin suppresses brain aging in senescence-accelerated OXYS rats.

Authors:  Nataliya G Kolosova; Anton O Vitovtov; Natalia A Muraleva; Andrey E Akulov; Natalia A Stefanova; Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2013-06       Impact factor: 5.682

4.  The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats.

Authors:  Nataliya G Kolosova; Natalia A Stefanova; Natalia A Muraleva; Vladimir P Skulachev
Journal:  Aging (Albany NY)       Date:  2012-10       Impact factor: 5.682

5.  Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties.

Authors:  Maria A Tikhonova; Tamara G Amstislavskaya; Victor M Belichenko; Larisa A Fedoseeva; Sergey P Kovalenko; Ekaterina E Pisareva; Alla S Avdeeva; Nataliya G Kolosova; Nikolai D Belyaev; Lyubomir I Aftanas
Journal:  BMC Neurosci       Date:  2018-04-19       Impact factor: 3.288
  5 in total

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