Literature DB >> 1117598

Polycythemia produced by hemoglobin Osler (beta-145 (HC2) Tyr yields Asp).

S Charache, B Brimhall, R T Jones.   

Abstract

Polycythemia in a black woman was associated with hemoglobin Osler. In this hemoglobin the tyrosine at the penultimate position of the beta chain is replaced by aspartic acid. As a result oxygen affinity of the hemoglobin is very high, heme-heme interaction is absent, and the influence of hydrogen ion and 2,3 diphosphoglycerate on oxygen affinity is attenuated.

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Year:  1975        PMID： 1117598

Source DB:  PubMed          Journal:  Johns Hopkins Med J        ISSN： 0021-7263


  3 in total

1.  Haemoglobin Rahere (beta Lys-Thr): A new high affinity haemoglobin associated with decreased 2, 3-diphosphoglycerate binding and relative polycythaemia.

Authors:  P A Lorkin; A D Stephens; M E Beard; P F Wrigley; L Adams; H Lehmann
Journal:  Br Med J       Date:  1975-10-25

2.  Hemoglobin McKees Rocks (alpha2beta2145Tyr leads to Term). A human "nonsense" mutation leading to a shortened beta-chain.

Authors:  R M Winslow; M L Swenberg; E Gross; P A Chervenick; R R Buchman; W F Anderson
Journal:  J Clin Invest       Date:  1976-03       Impact factor: 14.808

3.  A proton nuclear magnetic resonance investigation of proximal histidyl residues in human normal and abnormal hemoglobins. A probe for the heme pocket.

Authors:  S Takahashi; A K Lin; C Ho
Journal:  Biophys J       Date:  1982-07       Impact factor: 4.033
  3 in total

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