Studies on pathophysiological effects of postalimentary lipemia in patients with ischemic heart disease.

The present studies were undertaken to elucidate the pathophysiological effects of postalimentary lipemia(PAL) induced by the intake of much animal fat in patients with ischemic heart disease(IHD) and the preventive measures against them. Results obtained were as follows: 1) Occurrence of augmentation of ischemic changes in ECG was demonstrated after fat intake. 2) After fat intake, lowering of arterial oxygen tension and heparin-induced increase in arterio-venous difference of oxygen tension in the forearm were observed. 3) PAL resulted in an acceleration of platelet adhesiveness as well as a shortening of plasms recalcification time and that of plasma prothrombin time. 4) It was revealed that red blood cells adsorbed fat on their membrane and then readily agglutinate together. 5) Removal of chylomicrons from the blood stream was accelerated by the intravenous injection of glucose. These results lead to the following conclusions: 1)PAL exerts a deleterious effect on the oxygen supply to the myocardium in patients with IHD and it is probably due to the disturbance of pulmonary function and that of oxygen diffusion and blood flow in the myocardium. 2) As one of preventive measures against the concurrent intake of carbohydrate in an appropriate quantity appears to be of use.