| Literature DB >> 11175772 |
Abstract
Haploinsufficiency of FOXL2, a new forkhead transcription factor, causes blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), a rare developmental disorder affecting the eyelid and sometimes the ovary. A new study implicates FOXL2 as the first human gene required for the maintenance of ovarian follicles. The discovery of FOXL2 may provide insight into the causes of idiopathic premature ovarian failure, a disease that burdens many infertile couples.Entities:
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Year: 2001 PMID： 11175772 DOI： 10.1038/84735
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330