Literature DB >> 11175298

An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree.

U Radhakrishna1, S Senol, H Herken, K Gucuyener, C Gehrig, J L Blouin, N A Akarsu, S E Antonarakis.   

Abstract

Bipolar affective disorder (BPAD), also known as manic-depressive illness, is a common complex, polygenic disorder characterised by recurrent cyclic episodes of mania and depression. Family, twin, and adoption studies strongly suggest a genetic predisposition/susceptibility to BPAD, but no genes have yet been identified. We studied a large Turkish pedigree, with an apparently autosomal dominant BPAD, which contained 13 affected individuals. The age of onset ranged from 15-40 with a mean of 25 years. The phenotypes consisted of recurrent manic and major depressive episodes, including suicidal attempts; there was usually full remission with lithium treatment. A genome-wide linkage analysis using a dominant mode of inheritance showed strong evidence for a BPAD susceptibility locus on chromosome 20p11.2-q11.2. The highest 2-point lod score of 4.34 at theta = 0 was obtained with markers D20S604, D20S470, D20S836 and D20S838 using a dominant model with full penetrance. Haplotype analysis enabled the mapping of the BPAD locus in this family between markers D20S186 and D20S109, to a region of approximately 42 cM.

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Year:  2001        PMID： 11175298     DOI： 10.1038/sj.ejhg.5200584

Source DB:  PubMed          Journal:  Eur J Hum Genet        ISSN： 1018-4813            Impact factor:   4.246


  10 in total

1.  Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.

Authors:  Matthew B McQueen; B Devlin; Stephen V Faraone; Vishwajit L Nimgaonkar; Pamela Sklar; Jordan W Smoller; Rami Abou Jamra; Margot Albus; Silviu-Alin Bacanu; Miron Baron; Thomas B Barrett; Wade Berrettini; Deborah Blacker; William Byerley; Sven Cichon; Willam Coryell; Nick Craddock; Mark J Daly; J Raymond Depaulo; Howard J Edenberg; Tatiana Foroud; Michael Gill; T Conrad Gilliam; Marian Hamshere; Ian Jones; Lisa Jones; Suh-Hang Juo; John R Kelsoe; David Lambert; Christoph Lange; Bernard Lerer; Jianjun Liu; Wolfgang Maier; James D Mackinnon; Melvin G McInnis; Francis J McMahon; Dennis L Murphy; Markus M Nothen; John I Nurnberger; Carlos N Pato; Michele T Pato; James B Potash; Peter Propping; Ann E Pulver; John P Rice; Marcella Rietschel; William Scheftner; Johannes Schumacher; Ricardo Segurado; Kristel Van Steen; Weiting Xie; Peter P Zandi; Nan M Laird
Journal:  Am J Hum Genet       Date:  2005-08-15       Impact factor: 11.025

2.  Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior.

Authors:  Y R Yang; J H Jung; S-J Kim; K Hamada; A Suzuki; H J Kim; J H Lee; O-B Kwon; Y K Lee; J Kim; E-K Kim; H-J Jang; D-S Kang; J-S Choi; C J Lee; J Marshall; H-Y Koh; C-J Kim; H Seok; S H Kim; J H Choi; Y-B Choi; L Cocco; S H Ryu; J-H Kim; P-G Suh
Journal:  Mol Psychiatry       Date:  2017-01-31       Impact factor: 15.992

3.  Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.

Authors:  Tadao Arinami; Tsuyuka Ohtsuki; Hiroki Ishiguro; Hiroshi Ujike; Yuji Tanaka; Yukitaka Morita; Mari Mineta; Masashi Takeichi; Shigeto Yamada; Akira Imamura; Koichi Ohara; Haruo Shibuya; Kenshiro Ohara; Yasuo Suzuki; Tatsuyuki Muratake; Naoshi Kaneko; Toshiyuki Someya; Toshiya Inada; Takeo Yoshikawa; Tomoko Toyota; Kazuo Yamada; Takuya Kojima; Sakae Takahashi; Ohmori Osamu; Takahiro Shinkai; Michiko Nakamura; Hiroshi Fukuzako; Tomo Hashiguchi; Shin-ich Niwa; Takuya Ueno; Hirokazu Tachikawa; Takafumi Hori; Takashi Asada; Shinichiro Nanko; Hiroshi Kunugi; Ryota Hashimoto; Norio Ozaki; Nakao Iwata; Mutsuo Harano; Heii Arai; Tohru Ohnuma; Ichiro Kusumi; Tsukasa Koyama; Hiroshi Yoneda; Yasuyuki Fukumaki; Hiroki Shibata; Sunao Kaneko; Hisashi Higuchi; Norio Yasui-Furukori; Yohtaro Numachi; Masanari Itokawa; Yuji Okazaki
Journal:  Am J Hum Genet       Date:  2005-10-12       Impact factor: 11.025

Review 4.  The genetics of schizophrenia and bipolar disorder: dissecting psychosis.

Authors:  N Craddock; M C O'Donovan; M J Owen
Journal:  J Med Genet       Date:  2005-03       Impact factor: 6.318

5.  Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14.

Authors:  B Etain; F Mathieu; M Rietschel; W Maier; M Albus; P McKeon; S Roche; C Kealey; D Blackwood; W Muir; F Bellivier; C Henry; C Dina; S Gallina; H Gurling; A Malafosse; M Preisig; F Ferrero; S Cichon; J Schumacher; S Ohlraun; M Borrmann-Hassenbach; P Propping; R Abou Jamra; T G Schulze; A Marusic; Z M Dernovsek; B Giros; T Bourgeron; A Lemainque; D Bacq; C Betard; C Charon; M M Nöthen; M Lathrop; M Leboyer
Journal:  Mol Psychiatry       Date:  2006-03-14       Impact factor: 15.992

6.  Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.

Authors:  Jessica Ross; Wade Berrettini; William Coryell; Elliot S Gershon; Judith A Badner; John R Kelsoe; Melvin G McInnis; Francis J McMahon; Dennis L Murphy; John I Nurnberger; Tatiana Foroud; John P Rice; William B Scheftner; Peter Zandi; Howard Edenberg; William Byerley
Journal:  Psychiatr Genet       Date:  2008-08       Impact factor: 2.458

7.  A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.

Authors:  K J Oedegaard; T A Greenwood; A Lunde; O B Fasmer; H S Akiskal; J R Kelsoe
Journal:  J Affect Disord       Date:  2009-10-12       Impact factor: 4.839

8.  A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain.

Authors:  B Etain; A Dumaine; F Mathieu; F Chevalier; C Henry; J-P Kahn; J Deshommes; F Bellivier; M Leboyer; S Jamain
Journal:  Mol Psychiatry       Date:  2009-01-06       Impact factor: 15.992

Review 9.  The Genetics of Response to and Side Effects of Lithium Treatment in Bipolar Disorder: Future Research Perspectives.

Authors:  Fanny Senner; Mojtaba Oraki Kohshour; Safa Abdalla; Sergi Papiol; Thomas G Schulze
Journal:  Front Pharmacol       Date:  2021-03-25       Impact factor: 5.810

10.  Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.

Authors:  Ricardo Segurado; Sevilla D Detera-Wadleigh; Douglas F Levinson; Cathryn M Lewis; Michael Gill; John I Nurnberger; Nick Craddock; J Raymond DePaulo; Miron Baron; Elliot S Gershon; Jenny Ekholm; Sven Cichon; Gustavo Turecki; Stephan Claes; John R Kelsoe; Peter R Schofield; Renee F Badenhop; J Morissette; Hilary Coon; Douglas Blackwood; L Alison McInnes; Tatiana Foroud; Howard J Edenberg; Theodore Reich; John P Rice; Alison Goate; Melvin G McInnis; Francis J McMahon; Judith A Badner; Lynn R Goldin; Phil Bennett; Virginia L Willour; Peter P Zandi; Jianjun Liu; Conrad Gilliam; Suh-Hang Juo; Wade H Berrettini; Takeo Yoshikawa; Leena Peltonen; Jouko Lönnqvist; Markus M Nöthen; Johannes Schumacher; Christine Windemuth; Marcella Rietschel; Peter Propping; Wolfgang Maier; Martin Alda; Paul Grof; Guy A Rouleau; Jurgen Del-Favero; Christine Van Broeckhoven; Julien Mendlewicz; Rolf Adolfsson; M Anne Spence; Hermann Luebbert; Linda J Adams; Jennifer A Donald; Philip B Mitchell; Nicholas Barden; Eric Shink; William Byerley; Walter Muir; Peter M Visscher; Stuart Macgregor; Hugh Gurling; Gursharan Kalsi; Andrew McQuillin; Michael A Escamilla; Victor I Reus; Pedro Leon; Nelson B Freimer; Henrik Ewald; Torben A Kruse; Ole Mors; Uppala Radhakrishna; Jean-Louis Blouin; Stylianos E Antonarakis; Nurten Akarsu
Journal:  Am J Hum Genet       Date:  2003-06-11       Impact factor: 11.025
  10 in total

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