| Literature DB >> 11173909 |
T Matsumoto1, S Nakamura, Y Jin-No, Y Sawa, J Hara, N Oshitani, T Arakawa, H Otani, H Nagura.
Abstract
Inflammatory bowel diseases (ulcerative colitis and Crohn's disease) are chronic long-lasting inflammatory diseases with yet unknown etiology. Recent advancement revealed that both diseases are associated with genetic predisposition and environmental factors such as luminal microorganisms and antigens. Crohn's disease is associated with histopathologic features such as granuloma formation and longitudinal ulceration. In this article we describe the role of granuloma in the immunopathogenesis of Crohn's disease. Granuloma of Crohn's disease may play crucial roles as antigen-presenting cites to memory type T cells, which leads to activation and proliferation of T cells. Antigens presented at granuloma may be closely related to the disease. Copyright 2001 S. Karger AG, BaselEntities:
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Year: 2001 PMID： 11173909 DOI： 10.1159/000051910
Source DB: PubMed Journal: Digestion ISSN： 0012-2823 Impact factor: 3.216