| Literature DB >> 11173908 |
T Kanai1, M Watanabe, A Okazawa, T Sato, T Hibi.
Abstract
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-gamma. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model. Copyright 2001 S. Karger AG, BaselEntities:
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Year: 2001 PMID： 11173908 DOI： 10.1159/000051909
Source DB: PubMed Journal: Digestion ISSN： 0012-2823 Impact factor: 3.216