Effect of nicardipine and magnesiumon cerebral infarction - brain surface perfusion technique.

The protective effect of pre- and postischemia treatment of the brain by surface perfusion with nicardipine (Nic) and/or magnesium (Mg) was evaluated in a rat focal cerebral ischemia model. Artificial cerebrospinal fluid was perfused into the subarachnoid space of rats, containing Nic or Nic/Mg prior to vessel occlusion and Nic/Mg after occlusion. Reductions in the total amount of glutamate in the microdialysis perfusate and the volume of infarction tissue stained with 2,3,5-triphenyltetrazolium chloride were significant in all treated groups, even in rats treated after ischemia. An additive effect of Mg was also observed. These results suggest that this method may have clinical applications in patients suffering from ischemic insult. Copyright 2001 S. Karger AG, Basel.