Literature DB >> 11173628

The Role of the Envelope Glycoprotein in the Depletion of T Helper Cells in Human Immunodeficiency Virus Infection.

Christian Jassoy1, Martin Heinkelein, Sieghart Sopper.   

Abstract

Infection with the human immunodeficiency virus (HIV) causes gradual depletion of CD4+ T helper lymphocytes and destruction of the lymphoid tissue, which ultimately leads to a fatal defect of the cellular immune system. Paramount to the understanding of the pathogenesis of HIV infection is to elucidate the mechanism which underlies the loss of T helper cells. Various ideas have been proposed in order to explain this issue. Several hypotheses have focused on the role of the envelope glycoprotein in this process. This review summarizes the data obtained and concepts proposed regarding the involvement of the HIV glycoprotein in the pathology of CD4+ T cell depletion.

Entities:  

Year:  1997        PMID： 11173628     DOI： 10.1007/bf02893356

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  92 in total

1.  HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

Authors:  T Dragic; V Litwin; G P Allaway; S R Martin; Y Huang; K A Nagashima; C Cayanan; P J Maddon; R A Koup; J P Moore; W A Paxton
Journal:  Nature       Date:  1996-06-20       Impact factor: 49.962

Review 2.  Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complexes.

Authors:  P Rácz; K Tenner-Rácz; C Kahl; A C Feller; P Kern; M Dietrich
Journal:  Prog Allergy       Date:  1986

3.  CD4+ lymphocyte depletion in HIV-infected patients is associated with gp120-immunoglobulin-complement attachment to CD4+ cells.

Authors:  V Daniel; C Süsal; A P Prodeus; R Weimer; R Zimmermann; A Huth-Kühne; G Opelz
Journal:  Vox Sang       Date:  1993       Impact factor: 2.144

Review 4.  Cell death: the significance of apoptosis.

Authors:  A H Wyllie; J F Kerr; A R Currie
Journal:  Int Rev Cytol       Date:  1980

Review 5.  HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.

Authors:  C Jassoy; B D Walker
Journal:  Springer Semin Immunopathol       Date:  1997

6.  Programmed cell death in AIDS-related HIV and SIV infections.

Authors:  M L Gougeon; S Garcia; J Heeney; R Tschopp; H Lecoeur; D Guetard; V Rame; C Dauguet; L Montagnier
Journal:  AIDS Res Hum Retroviruses       Date:  1993-06       Impact factor: 2.205

7.  Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus.

Authors:  R S Blumberg; T Paradis; K L Hartshorn; M Vogt; D D Ho; M S Hirsch; J Leban; V L Sato; R T Schooley
Journal:  J Infect Dis       Date:  1987-12       Impact factor: 5.226

8.  Random depletion of T cells that bear specific T cell receptor V beta sequences in AIDS patients.

Authors:  D M Boldt-Houle; C R Rinaldo; G D Ehrlich
Journal:  J Leukoc Biol       Date:  1993-11       Impact factor: 4.962

9.  Antibody-dependent cellular cytotoxicity-inducing antibodies against human immunodeficiency virus. Presence at different clinical stages.

Authors:  K Ljunggren; B Böttiger; G Biberfeld; A Karlson; E M Fenyö; M Jondal
Journal:  J Immunol       Date:  1987-10-01       Impact factor: 5.422

10.  MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection.

Authors:  A Karlsson; K Parsmyr; E Sandström; E M Fenyö; J Albert
Journal:  J Clin Microbiol       Date:  1994-02       Impact factor: 5.948
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