Literature DB >> 11173566

Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen.

Béla Szende1, Ernô Tyihák, Gyula Szókán, György Kátay.   

Abstract

PC-3 human prostate carcinoma cells were treated with 100 mg/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formal-demethone with HCHO, applied simultaneously with Me-Asc in 10 mg/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed.

Entities:  

Year:  1995        PMID： 11173566     DOI： 10.1007/bf02893582

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  19 in total

1.  Formaldehyde-induced cytotoxic, genotoxic and mutagenic response in human lymphocytes and Salmonella typhimurium.

Authors:  E Schmid; W Göggelmann; M Bauchinger
Journal:  Mutagenesis       Date:  1986-11       Impact factor: 3.000

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Authors:  J E Sulston; H R Horvitz
Journal:  Dev Biol       Date:  1977-03       Impact factor: 3.582

Review 3.  Apoptosis and disease.

Authors:  D A Carson; J M Ribeiro
Journal:  Lancet       Date:  1993-05-15       Impact factor: 79.321

4.  Apoptotic cell death induced by c-myc is inhibited by bcl-2.

Authors:  R P Bissonnette; F Echeverri; A Mahboubi; D R Green
Journal:  Nature       Date:  1992-10-08       Impact factor: 49.962

5.  The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride.

Authors:  R J Graves; R D Callander; T Green
Journal:  Mutat Res       Date:  1994-02       Impact factor: 2.433

6.  Steady state kinetics of chloroperoxidase-catalyzed N-demethylation reactions.

Authors:  G L Kedderis; P F Hollenberg
Journal:  J Biol Chem       Date:  1983-10-25       Impact factor: 5.157

7.  Combined effect of cytostatic drugs and E-N-L-trimethyl lysine in healthy and transplantable tumor bearing mice.

Authors:  B Szende; K Lapis; K Simon
Journal:  Neoplasma       Date:  1982       Impact factor: 2.575

8.  [Ascorbigen and its derivatives--depot preparations of ascorbic acid].

Authors:  Iu V Bukin; I L Plikhtiak; V A Draudin-Krylenko; I V Iartseva; L M Orlova
Journal:  Bioorg Khim       Date:  1987-04

9.  The formaldehyde-donating activity of N5,N10-methylene tetrahydrofolic acid in xenobiotic biotransformation.

Authors:  N Kucharczyk; J T Yang; K K Wong; R D Sofia
Journal:  Xenobiotica       Date:  1984-08       Impact factor: 1.908

Review 10.  Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

Authors:  J F Kerr; A H Wyllie; A R Currie
Journal:  Br J Cancer       Date:  1972-08       Impact factor: 7.640
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  2 in total

1.  Formaldehyde promotes and inhibits the proliferation of cultured tumour and endothelial cells.

Authors:  E Tyihák; J Bocsi; F Timár; G Rácz; B Szende
Journal:  Cell Prolif       Date:  2001-06       Impact factor: 6.831

2.  Effective stimulation of the biotechnological potential of the medicinal white rot fungus: Phellinus pini by menadione-mediated oxidative stress.

Authors:  Magdalena Jaszek; Katarzyna Kos; Anna Matuszewska; Marcin Grąz; Dawid Stefaniuk; Monika Osińska-Jaroszuk; Monika Prendecka; Ewa Jóźwik; Krzysztof Grzywnowicz
Journal:  Appl Biochem Biotechnol       Date:  2014-08-03       Impact factor: 2.926
  2 in total

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