Literature DB >> 11173119

HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved?

D E Undlien1, B A Lie, E Thorsby.   

Abstract

The predisposition to develop a majority of autoimmune diseases is associated with specific genes within the human leukocyte antigen (HLA) complex. However, it is frequently difficult to determine which of the many genes of the HLA complex are directly involved in the disease process. The main reasons for these difficulties are the complexity of associations where several HLA complex genes might be involved, and the strong linkage disequilibrium that exists between the genes in this complex. The latter phenomenon leads to secondary disease associations, or what has been called 'hitchhiking polymorphisms'. Here, we give an overview of the complexity of HLA associations in autoimmune disease, focusing on type 1 diabetes and trying to answer the question: how many and which HLA genes are directly involved?

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Year:  2001        PMID： 11173119     DOI： 10.1016/s0168-9525(00)02180-6

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  18 in total

1.  Novel analytical methods applied to type 1 diabetes genome-scan data.

Authors:  Flemming Pociot; Allan E Karlsen; Claus B Pedersen; Mogens Aalund; Jørn Nerup
Journal:  Am J Hum Genet       Date:  2004-03-11       Impact factor: 11.025

2.  The association between HLA DQ genetic polymorphism and type 1 diabetes in a case-parent study conducted in an admixed population.

Authors:  Adriana Mimbacas; Fernando Pérez-Bravo; Jose Luis Santos; Carmen Pisciottano; Rosario Grignola; Gerardo Javiel; Ana Maria Jorge; Horacio Cardoso
Journal:  Eur J Epidemiol       Date:  2004       Impact factor: 8.082

3.  The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.

Authors:  L C Stene; P M Thorsby; J P Berg; K S Rønningen; D E Undlien; G Joner
Journal:  Diabetologia       Date:  2006-05-12       Impact factor: 10.122

4.  FokI polymorphism, vitamin D receptor, and interleukin-1 receptor haplotypes are associated with type 1 diabetes in the Dalmatian population.

Authors:  Tatijana Zemunik; Veselin Skrabic; Vesna Boraska; Dijaneta Diklic; Ivana Marinovic Terzic; Vesna Capkun; Marijana Peruzovic; Janos Terzic
Journal:  J Mol Diagn       Date:  2005-11       Impact factor: 5.568

5.  Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?

Authors:  M-C Tessier; H-Q Qu; R Fréchette; F Bacot; R Grabs; S P Taback; M L Lawson; S E Kirsch; T J Hudson; C Polychronakos
Journal:  J Med Genet       Date:  2005-07-13       Impact factor: 6.318

Review 6.  Type 1 diabetes and polyglandular autoimmune syndrome: A review.

Authors:  Martin P Hansen; Nina Matheis; George J Kahaly
Journal:  World J Diabetes       Date:  2015-02-15

7.  Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations.

Authors:  N Safra; N C Pedersen; Z Wolf; E G Johnson; H W Liu; A M Hughes; A Young; D L Bannasch
Journal:  Vet J       Date:  2011-07-07       Impact factor: 2.688

8.  The emerging global epidemic of type 1 diabetes.

Authors:  Jaakko Tuomilehto
Journal:  Curr Diab Rep       Date:  2013-12       Impact factor: 4.810

9.  Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.

Authors:  Clayton E Mathews; Robert T Graser; Rebecca J Bagley; Jason W Caldwell; Renhua Li; Gary A Churchill; David V Serreze; Edward H Leiter
Journal:  Immunogenetics       Date:  2003-09-25       Impact factor: 2.846

Review 10.  The major histocompatibility complex: a model for understanding graft-versus-host disease.

Authors:  Effie W Petersdorf
Journal:  Blood       Date:  2013-07-22       Impact factor: 22.113
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