Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain.

Apolipoprotein E (apoE) deficient mice were bred onto the C57BL/6 and FVB/N strain backgrounds. The cognitive behavior of food-restricted apoE-deficient and wildtype male mice from these strains was assessed in an olfactory cued 8-arm radial maze. At 6 weeks of age, all four types of mice improved in maze performance over the course of 5 days. However, at 6 months of age, only the apoE-deficient mice on the C57BL/6 background failed to improve their maze performance over the 5 day course, as gauged by the number of incorrect choices made before retrieving both food rewards. Thus, an age-dependent and strain-specific effect of apoE deficiency on cognitive behavior was observed in these mice. The background strain affected activity levels in the maze, as well as in an open field assay. Plasma corticosterone levels were assessed in control, fasted, and post-restraint stress states. Fasting and restraint stress led to increases in plasma corticosterone levels. Although there were strain specific effects on fasting corticosterone levels, and the effect of apoE deficiency on post-stress corticosterone levels, there was no association between fasted corticosterone levels and impaired cognitive behavior in the 8-arm radial maze assay.