Literature DB >> 1117298

A study of sensitivity to curare in myasthenic disorders using a regionaltechnique.

J C Brown, J E Charlton.   

Abstract

A study of curare sensitivity has been made in ocular myasthenia, myasthenia gravis, and the myasthenic syndrome sometimes associated with carcinoma, using a regional technique. Sensitivity is greater than in normal subjects. The injection of 0-125 mg d-tubocurarine resulted in a neuromuscular transmission block in all but a few of those cases with ocular myasthenia and in all cases of generalized myasthenia. Furthermore, the block persisted for longer than in normal subjects after the release of the tourniquet. This sensitivity to curare was not directly related to myasthenic weakness. The reasons for this are discussed and an explanation for such curare sensitivity is suggested.

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Year:  1975        PMID： 1117298      PMCID： PMC491856          DOI： 10.1136/jnnp.38.1.27

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  10 in total

1.  AN ELECTROPHYSIOLOGICAL INVESTIGATION OF NEUROMUSCULAR TRANSMISSION IN MYASTHENIA GRAVIS.

Authors:  D ELMQVIST; W W HOFMANN; J KUGELBERG; D M QUASTEL
Journal:  J Physiol       Date:  1964-11       Impact factor: 5.182

2.  The effect of guanidine on neuromuscular transmission.

Authors:  M OTSUKA; M ENDO
Journal:  J Pharmacol Exp Ther       Date:  1960-03       Impact factor: 4.030

3.  Studies in neuromuscular function. VI. Effects of anticholinesterase compounds, d-tubocurarine, and decamethonium in patients with myasthenia gravis.

Authors:  D GROB; A M HARVEY; R J JOHNS
Journal:  Bull Johns Hopkins Hosp       Date:  1956-10

4.  Sensitivity of myasthenia gravis patients to tubocurarine and decamethonium.

Authors:  E W PELIKAN; J E TETHER; K R UNNA
Journal:  Neurology       Date:  1953-04       Impact factor: 9.910

5.  A regional technique for the study of sensitivity to curare in human muscle.

Authors:  J C Brown; J E Charlton; D J White
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-01       Impact factor: 10.154

6.  A new theory of the termination of action of the muscle relaxants.

Authors:  S A Feldman; M F Tyrrell
Journal:  Proc R Soc Med       Date:  1970-07

7.  Alterations in reactivity to acetylcholine in myasthenia gravis and carcinomatous myopathy.

Authors:  D Grob; T Namba; D S Feldman
Journal:  Ann N Y Acad Sci       Date:  1966-01-26       Impact factor: 5.691

8.  Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma.

Authors:  D Elmqvist; E H Lambert
Journal:  Mayo Clin Proc       Date:  1968-10       Impact factor: 7.616

9.  Intermittent defect of acetylcholine release in myasthenia gravis.

Authors:  M Takamori; L Gutmann
Journal:  Neurology       Date:  1971-01       Impact factor: 9.910

10.  Clinical and physiological studies of the effect of guanidine of patients with myasthenia gravis.

Authors:  J C Brown; R J Johns
Journal:  Johns Hopkins Med J       Date:  1969-01
  10 in total
  7 in total

1.  Study of sensitivity to curare in certain neurological disorders using a regional technique.

Authors:  J C Brown; J E Charlton
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-01       Impact factor: 10.154

2.  Sevoflurane-induced sensitivity of neuromuscular function in a patient with myasthenia gravis in true remission.

Authors:  J Takeda; Y Ohnishi; T Koitabashi; K Fukushima
Journal:  J Anesth       Date:  1997-06       Impact factor: 2.078

3.  Anaesthesia for trans-sternal thymectomy in myasthenia gravis.

Authors:  N Redfern; P J McQuillan; I D Conacher; D T Pearson
Journal:  Ann R Coll Surg Engl       Date:  1987-11       Impact factor: 1.891

4.  Physiological characterisation of the "warm up" effect of activity in patients with myotonic dystrophy.

Authors:  R G Cooper; M J Stokes; R H Edwards
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-09       Impact factor: 10.154

5.  Anesthetic management of a patient suspected of having Lambert-Eaton syndrome due to an unexpected prolongation of vecuronium.

Authors:  Kouichiro Minami; Takeyoshi Sata; Hiroshi Ishimura; Yuko Tomotari; Akio Shigematsu
Journal:  J Anesth       Date:  1994-12       Impact factor: 2.078

6.  Treatment of myasthenia gravis. Report on 139 patients.

Authors:  C Scoppetta; P Tonali; A Evoli; P David; F Crucitti; M L Vaccario
Journal:  J Neurol       Date:  1979       Impact factor: 4.849

7.  Sensitivity to vecuronium in myasthenia gravis: a dose-response study.

Authors:  J B Eisenkraft; W J Book; A E Papatestas
Journal:  Can J Anaesth       Date:  1990-04       Impact factor: 5.063
  7 in total

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