Literature DB >> 11172812

Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors.

S McGonigle1, M J Beall, E L Feeney, E J Pearce.   

Abstract

Schistosoma mansoni receptor kinase-1 (SmRK1) is a divergent type I transforming growth factor beta (TGFbeta) receptor on the surface of adult parasites. Using the intracellular domain of SmRK1 as bait in a yeast two-hybrid screen we identified an interaction with S. mansoni 14-3-3epsilon. The interaction which is phosphorylation-dependent is not specific to schistosomes since 14-3-3epsilon also binds to TbetaRI, the human type I TGFbeta receptor. 14-3-3epsilon enhances TGFbeta-mediated signaling by TbetaRI and is the first TbetaRI-interacting non-Smad protein identified that positively regulates this receptor. The interaction of 14-3-3epsilon with schistosome and human TbetaRI suggests a conserved, but previously unappreciated, role for this protein in TGFbeta signaling pathways.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11172812     DOI： 10.1016/s0014-5793(01)02133-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  14-3-3epsilon controls multiple developmental processes in the mouse heart.

Authors:  Adriana C Gittenberger-de Groot; Tamara Hoppenbrouwers; Lucile Miquerol; Yasuhiro Kosaka; Robert E Poelmann; Lambertus J Wisse; H Joseph Yost; Monique R M Jongbloed; Marco C Deruiter; Luca Brunelli
Journal:  Dev Dyn       Date:  2016-09-18       Impact factor: 3.780

2.  Identification and molecular characterization of a novel signaling molecule 14-3-3 epsilon in Clonorchis sinensis excretory/secretory products.

Authors:  Xiaoyun Wang; Wenjun Chen; Xuerong Li; Chenhui Zhou; Chuanhuan Deng; Xiaoli Lv; Yongxiu Fan; Jingtao Men; Chi Liang; Xinbing Yu
Journal:  Parasitol Res       Date:  2011-09-16       Impact factor: 2.289

3.  14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.

Authors:  Jing Lu; Hua Guo; Warapen Treekitkarnmongkol; Ping Li; Jian Zhang; Bin Shi; Chen Ling; Xiaoyan Zhou; Tongzhen Chen; Paul J Chiao; Xinhua Feng; Victoria L Seewaldt; William J Muller; Aysegul Sahin; Mien-Chie Hung; Dihua Yu
Journal:  Cancer Cell       Date:  2009-09-08       Impact factor: 31.743

Review 4.  TGF-β Signaling from Receptors to Smads.

Authors:  Akiko Hata; Ye-Guang Chen
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-09-01       Impact factor: 10.005

5.  Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation.

Authors:  Ana Lonic; Emma F Barry; Cindy Quach; Bostjan Kobe; Neil Saunders; Mark A Guthridge
Journal:  Mol Cell Biol       Date:  2008-03-10       Impact factor: 4.272

6.  14-3-3 gene characterization and description of a second 14-3-3 isoform in both Echinococcus granulosus and E. multilocularis.

Authors:  Cláudia Paiva Nunes; Arnaldo Zaha; Bruno Gottstein; Norbert Müller; María del Mar Siles-Lucas
Journal:  Parasitol Res       Date:  2004-06-25       Impact factor: 2.289

Review 7.  Schistosoma mansoni: TGF-beta signaling pathways.

Authors:  Philip T Loverde; Ahmed Osman; Andrew Hinck
Journal:  Exp Parasitol       Date:  2007-06-16       Impact factor: 2.011

8.  Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.

Authors:  Jun-ichi Iwata; Joseph G Hacia; Akiko Suzuki; Pedro A Sanchez-Lara; Mark Urata; Yang Chai
Journal:  J Clin Invest       Date:  2012-02-13       Impact factor: 19.456

9.  14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature.

Authors:  Jun Yang; Sonali Joshi; Qingfei Wang; Ping Li; Hai Wang; Yan Xiong; Yi Xiao; Jinyang Wang; Jan Parker-Thornburg; Richard R Behringer; Dihua Yu
Journal:  Cell Biosci       Date:  2017-11-02       Impact factor: 7.133

10.  Interaction of hookworm 14-3-3 with the forkhead transcription factor DAF-16 requires intact Akt phosphorylation sites.

Authors:  Joshua E Kiss; Xin Gao; Joseph M Krepp; John M Hawdon
Journal:  Parasit Vectors       Date:  2009-04-24       Impact factor: 3.876
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.