| Literature DB >> 11171913 |
H Shinotoh1, A Aotsuka, K Fukushi, S Nagatsuka, N Tanaka, T Ota, S Tanada, T Irie.
Abstract
Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two patients, 3 mg/d in one patient) using PET and N-[11C]methylpiperidin-4-yl acetate. Donepezil reduced k(3) values, an index of AChE activity, in the cerebral cortex by 39 +/- 5%. All patients showed some degree of symptomatic improvement, and it was concluded that this improvement was likely caused by improved cholinergic activity by inhibition of AChE in the brain.Entities:
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Year: 2001 PMID： 11171913 DOI： 10.1212/wnl.56.3.408
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910