Literature DB >> 111716

Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone.

P Coleman, C Kettner, E Shaw.   

Abstract

The binding specificities of human urinary urokinase (EC 3.4.99.26) and HeLa cell plasminogen activator were studied using peptidyl chloromethyl ketone inhibitors. A 125I-labeled fibrin assay has been developed to yield kinetic information. Reagents of the sequence X-Gly-ArgCH2Cl were the most effective. The susceptibility of the HeLa cell plasminogen activator differed from that of urokinase in several respects indicating the utility of this type of inhibitor in distinguishing between proteases of this specificity.

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Year:  1979        PMID： 111716     DOI： 10.1016/0005-2744(79)90079-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  Active site directed inhibitor used in the production of antibodies against urokinase.

Authors:  S A Cederholm-Williams; J M Marshall; H Chissic
Journal:  J Clin Pathol       Date:  1984-10       Impact factor: 3.411

2.  In vivo distribution of Tc-99m labeled recombinant tissue-type plasminogen activator in control and thrombus-bearing rats.

Authors:  E Tsukamoto
Journal:  Ann Nucl Med       Date:  1992-08       Impact factor: 2.668
  2 in total

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