| Literature DB >> 11170689 |
P Waffo-Teguo1, D Lee, M Cuendet, J Mérillon, J M Pezzuto, A D Kinghorn.
Abstract
Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-beta-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11'-O-beta-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC(50) values in the range of 5 microM, whereas compound 4 was approximately 10-fold less active.Entities:
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Year: 2001 PMID： 11170689 DOI： 10.1021/np000426r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050