Literature DB >> 11170679

Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa.

J E van Der Kaaden1, T K Hemscheidt, S L Mooberry.   

Abstract

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC(50) value of 1.3 microM in both cases.

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Year:  2001        PMID： 11170679     DOI： 10.1021/np000265r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  A Stilbenoid-Specific Prenyltransferase Utilizes Dimethylallyl Pyrophosphate from the Plastidic Terpenoid Pathway.

Authors:  Tianhong Yang; Lingling Fang; Agnes M Rimando; Victor Sobolev; Keithanne Mockaitis; Fabricio Medina-Bolivar
Journal:  Plant Physiol       Date:  2016-06-29       Impact factor: 8.340

2.  Synthesis and structure activity relationships of schweinfurthin indoles.

Authors:  John G Kodet; John A Beutler; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2014-03-06       Impact factor: 3.641

3.  Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.

Authors:  Jin Tatsuzaki; Kenneth F Bastow; Kyoko Nakagawa-Goto; Seiko Nakamura; Hideji Itokawa; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2006-10       Impact factor: 4.050

4.  Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

Authors:  Brent J Yoder; Shugeng Cao; Andrew Norris; James S Miller; Fidy Ratovoson; Jeremi Razafitsalama; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-02-28       Impact factor: 4.050
  4 in total

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