Literature DB >> 1117061

Plasma glucagon and alanine responses to acute insulin deficiency in man.

J E Gerich, E Tsalikian, M Lorenzi, J H Karam, D M Bier.   

Abstract

Plasma glucagon levels rose within 1 hr after withdrawal of insulin in 7 juvenile-type diabetics previously kept normoglycemic by prolonged intravenous infusions of insulin. These changes preceded subsequent elevations in plasma alanine levels. Individual rises in plasma glucagon were correlated with elevations in plasma glucose, beta-hydroxybutyrate, free fatty acid, and glycerol levels, suggesting that glucagon may play an important role in the development of diabetic ketoacidosis in man.

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Year:  1975        PMID： 1117061     DOI： 10.1210/jcem-40-3-526

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  7 in total

1.  Regulation of glucagon release: effects of insulin on the pancreatic A2-cell of the guinea pig.

Authors:  C G Ostenson
Journal:  Diabetologia       Date:  1979-11       Impact factor: 10.122

2.  The effect of short-term intravenous insulin administration on the glucagon response to a carbohydrate meal in adult onset and juvenile type diabetes.

Authors:  I Aydin; P Raskin; R H Unger
Journal:  Diabetologia       Date:  1977-12       Impact factor: 10.122

3.  The contribution of endogenous insulin secretion to the ketogenic response to glucagon in man.

Authors:  D S Schade; R P Eaton
Journal:  Diabetologia       Date:  1975-12       Impact factor: 10.122

4.  Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin.

Authors:  J E Gerich; M Lorenzi; D M Bier; E Tsalikian; V Schneider; J H Karam; P H Forsham
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

5.  Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes.

Authors:  Ian R Lanza; Shucha Zhang; Lawrence E Ward; Helen Karakelides; Daniel Raftery; K Sreekumaran Nair
Journal:  PLoS One       Date:  2010-05-10       Impact factor: 3.240

6.  Comparison of the suppressive effects of elevated plasma glucose and free fatty acid levels on glucagon secretion in normal and insulin-dependent diabetic subjects. Evidence for selective alpha-cell insensitivity to glucose in diabetes mellitus.

Authors:  J E Gerich; M Langlois; C Noacco; M Lorenzi; J H Karam; P H Korsham
Journal:  J Clin Invest       Date:  1976-08       Impact factor: 14.808

7.  Glucagon regulation of plasma ketone body concentration in human diabetes.

Authors:  D S Schade; R P Eaton
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808
  7 in total

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