Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.

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18 in total

1. Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1.

Authors: Amos B Smith; Chris Sfouggatakis; Christina A Risatti; Jeffrey B Sperry; Wenyu Zhu; Victoria A Doughty; Takashi Tomioka; Dimitar B Gotchev; Clay S Bennett; Satoshi Sakamoto; Onur Atasoylu; Shohei Shirakami; David Bauer; Makoto Takeuchi; Jyunichi Koyanagi; Yasuharu Sakamoto
Journal: Tetrahedron Date: 2009-09-15 Impact factor: 2.457

2. Ortho-TMS benzaldehyde: an effective linchpin for type II anion relay chemistry (ARC).

Authors: Amos B Smith; Won-Suk Kim; William M Wuest
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

Review 3. Conformation-activity relationships of polyketide natural products.

Authors: Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal: Nat Prod Rep Date: 2015-08 Impact factor: 13.423

4. Studies toward the synthesis of spirolide C: exploration into the formation of the 23-membered all-carbon macrocyclic framework.

Authors: Craig E Stivala; Zhenhua Gu; Lindsay L Smith; Armen Zakarian
Journal: Org Lett Date: 2012-01-19 Impact factor: 6.005

1. Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1.

2. Ortho-TMS benzaldehyde: an effective linchpin for type II anion relay chemistry (ARC).

Review 3. Conformation-activity relationships of polyketide natural products.

4. Studies toward the synthesis of spirolide C: exploration into the formation of the 23-membered all-carbon macrocyclic framework.

5. Exploiting pseudo C2-symmetry for an efficient synthesis of the F-ring of the spongistatins.

6. α-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry.

Review 7. Evolution of Anion Relay Chemistry: Construction of Architecturally Complex Natural Products.

8. Diversity-oriented synthesis of 2,4,6-trisubstituted piperidines via type II anion relay chemistry.

9. Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned.

10. Benzyl and phenylthiomethyl silanes: a new class of bifunctional linchpins for type II anion relay chemistry (ARC).