| Literature DB >> 11169267 |
K Bogunia-Kubik1, J Tomeczko, K Suchnicki, A Lange.
Abstract
Determination of DRB1 and DRB3 specificities in sarcoidosis patients identified that the presence of DRB1*03 and the absence of DRB1*11 and/or DRB1*12 favors a course of disease that is associated positively with Löfgren's syndrome (DRB1*03) and negatively with stage I disease (DRB1*11 and/or 12). In common with normal controls, DRB1*03 was associated with DRB3*0101 and DRB1*11/12 with DRB3*0201/2. An analysis of DRB1 and DRB3 associations in variants of sarcoidosis revealed that DRB1*03 and DRB3*0101 were associated with Löfgren's syndrome in a combined association fashion. Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.Entities:
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Year: 2001 PMID： 11169267 DOI： 10.1034/j.1399-0039.2001.057001087.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815