Literature DB >> 11167832

Epstein-Barr virus-positive aggressive lymphoma as a consequence of immunosuppression after multiple salvage treatments for follicular lymphoma.

E Orlandi1, M Paulli, A Viglio, G Pagnucco, R Riboni, F Baldanti, M Lazzarino.   

Abstract

We report on a patient with follicular non-Hodgkin's lymphoma (NHL) who developed a fatal high-grade Epstein-Barr virus (EBV)-positive NHL after conventional chemotherapies. The sudden onset of the high-grade lymphoma was accompanied by increasing circulating EBV genome copies and was complicated by spontaneous rupture of the spleen. Splenic tissue was diffusely infiltrated by large B cells. In situ hybridization for Epstein-Barr-encoded RNA (EBER) 1-2 was positive in 70% of cells, and molecular analysis revealed the presence of EBV DNA and a monoclonal IgH gene rearrangement. This case shows that the immunosuppression of multiple treatments may induce uncontrolled reactivation of a latent EBV infection, contributing to high-grade transformation in heavily treated lymphoma patients.

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Year:  2001        PMID： 11167832     DOI： 10.1046/j.1365-2141.2001.02579.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  10 in total

1.  ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.

Authors:  Joseph M Kulinski; Eric J Darrah; Katarzyna A Broniowska; Wadzanai P Mboko; Bryan C Mounce; Laurent P Malherbe; John A Corbett; Stephen B Gauld; Vera L Tarakanova
Journal:  Virology       Date:  2015-05-21       Impact factor: 3.616

Review 2.  Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature.

Authors:  Massimo Granai; Maria Raffaella Ambrosio; Ayse Akarca; Lucia Mundo; Federica Vergoni; Raffaella Santi; Virginia Mancini; Gioia di Stefano; Teresa Amato; Cristiana Bellan; Benedetta Puccini; Ester Sorrentino; Kikkeri N Naresh; Lorenzo Leoncini; Teresa Marafioti; Stefano Lazzi
Journal:  Haematologica       Date:  2019-03-07       Impact factor: 9.941

3.  ATM supports gammaherpesvirus replication by attenuating type I interferon pathway.

Authors:  Eric J Darrah; Kyle P Stoltz; Mitchell Ledwith; Vera L Tarakanova
Journal:  Virology       Date:  2017-07-18       Impact factor: 3.616

4.  Epstein-Barr virus-positive follicular lymphoma.

Authors:  Nicholas Mackrides; German Campuzano-Zuluaga; Yvan Maque-Acosta; Adrienne Moul; Nouf Hijazi; Francis Offiong Ikpatt; Ronald Levy; Ramiro E Verdun; Kranthi Kunkalla; Yasodha Natkunam; Izidore S Lossos; Francisco Vega; Jennifer Chapman
Journal:  Mod Pathol       Date:  2016-12-16       Impact factor: 7.842

5.  T Cell-Intrinsic Interleukin 17 Receptor A Signaling Supports the Establishment of Chronic Murine Gammaherpesvirus 68 Infection.

Authors:  C N Jondle; V L Tarakanova
Journal:  J Virol       Date:  2022-06-27       Impact factor: 6.549

6.  LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.

Authors:  P T Lange; C N Jondle; E J Darrah; K E Johnson; V L Tarakanova
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

7.  EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies.

Authors:  Deirdre O'Mahony; John C Morris; Maryalice Stetler-Stevenson; Helen Matthews; Margaret R Brown; Thomas Fleisher; Stefania Pittaluga; Mark Raffeld; Paul S Albert; Dirk Reitsma; Karen Kaucic; Luz Hammershaimb; Thomas A Waldmann; John E Janik
Journal:  Clin Cancer Res       Date:  2009-03-17       Impact factor: 12.531

8.  Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection.

Authors:  K E Johnson; C A Aurubin; C N Jondle; P T Lange; V L Tarakanova
Journal:  J Virol       Date:  2020-11-23       Impact factor: 5.103

9.  Clinicopathologic study of mantle cell lymphoma with epstein-barr virus infection: A case series and literature review.

Authors:  Xiaoju Li; Fanlin Zhou; Shijie Li; Yangyang Wang; Jianing Fan; Xiao Liang; Yan Peng; Yudi Jin; Weiyang Jiang; Fang Liu; Yixing Zhou; Shuke Liu; Tao Wang; Yi Peng; Jianbo Xiong; Jia Liu; Jing Zhang; Changqing He; Hui Zhang; Yu Li
Journal:  Front Oncol       Date:  2022-08-02       Impact factor: 5.738

10.  Secondary Hemophagocytic Lymphohistiocytosis With Epstein-Barr Virus-Associated Transformed Follicular Lymphoma: A Case Report and Literature Review.

Authors:  Huan Xu; Xia Xu; Guohui Cui; Jun Fang; Wanxin Chen; Mei Xue; Runming Jin; Hongbo Chen; Lu Zhang; Yu Hu
Journal:  Front Oncol       Date:  2021-06-25       Impact factor: 6.244
  10 in total

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