Literature DB >> 11166940

Prepro-galanin messenger RNA levels are increased in rat locus coeruleus after treadmill exercise training.

H A O'Neal1, J D Van Hoomissen, P V Holmes, R K Dishman.   

Abstract

The effects of treadmill exercise training on prepro-galanin (GAL) and tyrosine hydroxylase (TH) gene expression in the locus coeruleus (LC) were examined. Male Fischer-344 rats (n=9) were assigned to 6 weeks of treadmill running. An additional group of animals comprised the sedentary home cage control group (n=9). Levels of GAL and TH messenger RNA (mRNA) in the LC were measured using in situ hybridization histochemistry with autoradiography. Levels of GAL mRNA were higher in treadmill trained animals compared to sedentary animals, but there was no effect of treadmill running on TH mRNA. These results suggest that gene expression for galanin is responsive to repeated exercise stress and may have a neuromodulatory role in LC-noradrenergic adaptation to treadmill exercise training.

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Year:  2001        PMID： 11166940     DOI： 10.1016/s0304-3940(00)01780-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  18 in total

1.  Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test.

Authors:  Takashi Yoshitake; Fu-Hua Wang; Eugenia Kuteeva; Kristina Holmberg; Masatoshi Yamaguchi; Jacqueline N Crawley; Robert Steiner; Tamas Bartfai; Sven Ove Ogren; Tomas Hökfelt; Jan Kehr
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-30       Impact factor: 11.205

Review 2.  Exercise offers anxiolytic potential: a role for stress and brain noradrenergic-galaninergic mechanisms.

Authors:  Natale R Sciolino; Philip V Holmes
Journal:  Neurosci Biobehav Rev       Date:  2012-07-05       Impact factor: 8.989

3.  The role of the neuropeptide galanin in forming type-specific behavioral characteristics.

Authors:  V I Lyudyno; I N Abdurasulova; V M Klimenko
Journal:  Neurosci Behav Physiol       Date:  2008-01

Review 4.  Biological mechanisms of physical activity in preventing cognitive decline.

Authors:  I Lista; G Sorrentino
Journal:  Cell Mol Neurobiol       Date:  2009-12-30       Impact factor: 5.046

5.  Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response.

Authors:  Paul G Unschuld; Marcus Ising; Darina Roeske; Angelika Erhardt; Michael Specht; Stefan Kloiber; Manfred Uhr; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Journal:  Neuropsychopharmacology       Date:  2010-03-17       Impact factor: 7.853

6.  Locus coeruleus galanin expression is enhanced after exercise in rats selectively bred for high capacity for aerobic activity.

Authors:  Patrick S Murray; Jessica L Groves; Brett J Pettett; Steven L Britton; Lauren G Koch; Rod K Dishman; Philip V Holmes
Journal:  Peptides       Date:  2010-09-16       Impact factor: 3.750

7.  The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats.

Authors:  Yvonne E Ogbonmwan; Jason P Schroeder; Philip V Holmes; David Weinshenker
Journal:  Psychopharmacology (Berl)       Date:  2014-10-31       Impact factor: 4.530

8.  Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.

Authors:  S Alisha Epps; Alexa B Kahn; Philip V Holmes; Katherine A Boss-Williams; Jay M Weiss; David Weinshenker
Journal:  Epilepsy Behav       Date:  2013-08-08       Impact factor: 2.937

Review 9.  Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

Authors:  David Weinshenker; Philip V Holmes
Journal:  Brain Res       Date:  2015-11-20       Impact factor: 3.252

10.  Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.

Authors:  Natale R Sciolino; Rodney K Dishman; Philip V Holmes
Journal:  Behav Brain Res       Date:  2012-05-09       Impact factor: 3.332
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