Literature DB >> 11166895

Prevention of vertical transmission of Neospora caninum in BALB/c mice by recombinant vaccinia virus carrying NcSRS2 gene.

Y Nishikawa1, X Xuan, H Nagasawa, I Igarashi, K Fujisaki, H Otsuka, T Mikami.   

Abstract

Neospora caninum infection is the major cause of bovine abortion. To develop a vaccine against N. caninum infection, recombinant vaccinia viruses carrying NcSRS2 and NcSAG1 genes (vv/Nc-p43 and vv/Nc-p36, respectively) were constructed and were tested in a mouse model. Vaccination of dams with vv/Nc-p43 appeared to confer effective protection against vertical transmission to offspring, though that with vv/Nc-p36 only provided partial protection. Moreover, the vv/Nc-p43 vaccination provoked cellular immune responses and antibody production against N. caninum. In conclusion, it is expected that vv/Nc-p43 can be used as an effective live vaccine to prevent vertical transmission of N. caninum in natural hosts.

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Year:  2001        PMID： 11166895     DOI： 10.1016/s0264-410x(00)00407-2

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  23 in total

1.  Inclusion of CpG adjuvant with plasmid DNA coding for NcGRA7 improves protection against congenital neosporosis.

Authors:  Mark Jenkins; Carolyn Parker; Wenbin Tuo; Bryan Vinyard; J P Dubey
Journal:  Infect Immun       Date:  2004-03       Impact factor: 3.441

2.  Characterization of Neospora caninum surface protein NcSRS2 based on baculovirus expression system and its application for serodiagnosis of Neospora infection.

Authors:  Y Nishikawa; Y Kousaka; K Tragoolpua; X Xuan; L Makala; K Fujisaki; T Mikami; H Nagasawa
Journal:  J Clin Microbiol       Date:  2001-11       Impact factor: 5.948

3.  Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection.

Authors:  Jung-Hwa Cho; Woo-Suk Chung; Kyoung-Ju Song; Byoung-Kuk Na; Seung-Won Kang; Chul-Yong Song; Tong-Soo Kim
Journal:  Korean J Parasitol       Date:  2005-03       Impact factor: 1.341

4.  Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death.

Authors:  D J L Williams; C S Guy; R F Smith; J Ellis; C Björkman; M P Reichel; A J Trees
Journal:  Infect Immun       Date:  2006-12-04       Impact factor: 3.441

5.  Determination of antigenic domain in GST fused major surface protein (Nc-p43) of Neospora caninum.

Authors:  E S Son; H J Ahn; J H Kim; D Y Kim; H W Nam
Journal:  Korean J Parasitol       Date:  2001-09       Impact factor: 1.341

6.  Tissue distribution of Neospora caninum in experimentally infected cattle.

Authors:  Maki Nishimura; Junko Kohara; Jun Hiasa; Yoshikage Muroi; Naoaki Yokoyama; Katsuya Kida; Xuenan Xuan; Hidefumi Furuoka; Yoshifumi Nishikawa
Journal:  Clin Vaccine Immunol       Date:  2012-12-12

7.  Characterization of tissue distribution and histopathological lesions in Neospora caninum experimentally infected gerbils.

Authors:  Seung-Won Kang; Sung-Soo Park; Se-Eun Choe; Young-Hwa Jean; Suk-Chan Jung; Keun Kim; Dong Van Quyen
Journal:  Parasitol Res       Date:  2009-01-27       Impact factor: 2.289

8.  Characterization of the B-cell immune response elicited in BALB/c mice challenged with Neospora caninum tachyzoites.

Authors:  Luzia Teixeira; Andreia Marques; Carla Sofia Meireles; Ana Rita Seabra; Diana Rodrigues; Pedro Madureira; Augusto M R Faustino; Carolina Silva; Adília Ribeiro; Paula Ferreira; José Manuel Correia da Costa; Nuno Canada; Manuel Vilanova
Journal:  Immunology       Date:  2005-09       Impact factor: 7.397

9.  Indoleamine 2,3-dioxygenase is involved in defense against Neospora caninum in human and bovine cells.

Authors:  Katrin Spekker; Markus Czesla; Vanessa Ince; Kathrin Heseler; Silvia K Schmidt; Gereon Schares; Walter Däubener
Journal:  Infect Immun       Date:  2009-07-20       Impact factor: 3.441

10.  Immunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice.

Authors:  Yoshifumi Nishikawa; Houshuang Zhang; Yuzuru Ikehara; Naoya Kojima; Xuenan Xuan; Naoaki Yokoyama
Journal:  Clin Vaccine Immunol       Date:  2009-04-08
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