Dyshaemopoietic bone marrow features in healthy subjects are related to age.

We have quantified bone marrow dyshaemopoietic features in 54 "healthy" people aged 18-85 without peripheral blood cytopenia and we have detected a statistically significant positive correlation between age and both bone marrow dyserythropoietic and dysgranulopoietic features (r=+0.70, p<0.001 and r=+0.275, p=0.044, respectively), as well as a negative correlation between age and bone marrow blast cell count (r=-0.329, p=0.016). After taking into account other covariates, smokers showed in their bone marrow, at any age, a 3.73% higher percentage of dyserythropoietic features and a 0.28% higher percentage of blast cells than non-smokers.