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Literature DB >> 11166572

The Rad51 and Dmc1 recombinases: a non-identical twin relationship.

Abstract

A double-strand break in genomic DNA that remains unrepaired can be lethal for a cell. Indeed, the integrity of the genome is paramount for survival. It is therefore surprising that some cells deliberately introduce double-strand breaks at certain times during their life cycle. Why might they do this? What are the benefits? How are these breaks repaired? The answers to these questions lie in understanding the basis of meiotic recombination, the process that leads to genetic variation. This review summarizes the key roles played by the two recombinases, Dmc1 and Rad51, in the faithful repair of DNA breaks.

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Year: 2001 PMID： 11166572 DOI： 10.1016/s0968-0004(00)01742-4

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

73 in total

1. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.

Authors: Michael A Crackower; Nadine K Kolas; Junko Noguchi; Renu Sarao; Kazuhiro Kikuchi; Hiroyuki Kaneko; Eiji Kobayashi; Yasuhiro Kawai; Ivona Kozieradzki; Rushin Landers; Rong Mo; Chi-Chung Hui; Edward Nieves; Paula E Cohen; Lucy R Osborne; Teiji Wada; Tetsuo Kunieda; Peter B Moens; Josef M Penninger
Journal: Science Date: 2003-05-23 Impact factor: 47.728

2. Genetic and cytological characterization of the RecA-homologous proteins Rad51 and Dmc1 of Schizosaccharomyces pombe.

Authors: Alexandra L Grishchuk; Rolf Kraehenbuehl; Monika Molnar; Oliver Fleck; Juerg Kohli
Journal: Curr Genet Date: 2003-08-29 Impact factor: 3.886

3. Altered nuclear distribution of recombination protein RAD51 in maize mutants suggests the involvement of RAD51 in meiotic homology recognition.

Authors: Wojciech P Pawlowski; Inna N Golubovskaya; W Zacheus Cande
Journal: Plant Cell Date: 2003-08 Impact factor: 11.277

10. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.

Authors: Lihong Wan; Teresa de los Santos; Chao Zhang; Kevan Shokat; Nancy M Hollingsworth
Journal: Mol Biol Cell Date: 2003-10-31 Impact factor: 4.138

The Rad51 and Dmc1 recombinases: a non-identical twin relationship.

1. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.

2. Genetic and cytological characterization of the RecA-homologous proteins Rad51 and Dmc1 of Schizosaccharomyces pombe.

3. Altered nuclear distribution of recombination protein RAD51 in maize mutants suggests the involvement of RAD51 in meiotic homology recognition.

4. Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.

5. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange.

6. A molecular portrait of Arabidopsis meiosis.

7. AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.

8. Two X family DNA polymerases, lambda and mu, in meiotic tissues of the basidiomycete, Coprinus cinereus.

9. Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.

10. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.