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Literature DB >> 11166571

Ribosome fidelity: tRNA discrimination, proofreading and induced fit.

Abstract

The ribosome selects aminoacyl-tRNAs with high fidelity. Kinetic studies reveal that codon-anticodon recognition both stabilizes aminoacyl-tRNA binding on the ribosome and accelerates reactions of the productive pathway, indicating an important contribution of induced fit to substrate selection. Similar mechanisms are used by other template-programmed enzymes, such as DNA and RNA polymerases.

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Year: 2001 PMID： 11166571 DOI： 10.1016/s0968-0004(00)01737-0

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

39 in total

1. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome.

Authors: Peter Geggier; Richa Dave; Michael B Feldman; Daniel S Terry; Roger B Altman; James B Munro; Scott C Blanchard
Journal: J Mol Biol Date: 2010-04-29 Impact factor: 5.469

2. Codon-dependent tRNA fluctuations monitored with fluorescence polarization.

Authors: Padmaja P Mishra; Mohd Tanvir Qureshi; Wenhui Ren; Tae-Hee Lee
Journal: Biophys J Date: 2010-12-01 Impact factor: 4.033

3. Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1.

Authors: Fatoum Kthiri; Valérie Gautier; Hai-Tuong Le; Marie-Françoise Prère; Olivier Fayet; Abderrahim Malki; Ahmed Landoulsi; Gilbert Richarme
Journal: J Bacteriol Date: 2010-10-01 Impact factor: 3.490

Ribosome fidelity: tRNA discrimination, proofreading and induced fit.

1. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome.

2. Codon-dependent tRNA fluctuations monitored with fluorescence polarization.

3. Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1.

4. The role of fluctuations in tRNA selection by the ribosome.

5. Bases in the anticodon loop of tRNA(Ala)(GGC) prevent misreading.

6. The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation.

7. FRET enabled real time detection of RNA-small molecule binding.

8. Translational selection and yeast proteome evolution.

9. Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes.

10. Natural amino acids do not require their native tRNAs for efficient selection by the ribosome.