| Literature DB >> 11166150 |
G Bellone1, A Carbone, D Tibaudi, F Mauri, I Ferrero, C Smirne, F Suman, C Rivetti, G Migliaretti, M Camandona, G Palestro, G Emanuelli, U Rodeck.
Abstract
Transforming growth factor (TGF)-beta is a protein family which affects multiple cellular functions including survival, proliferation, differentiation and adhesion. Among the three known isoforms, TGF-beta1 is commonly overexpressed in solid malignancies. Recent studies in knock-out mice demonstrated non-redundant roles of different TGF-beta isoforms in development. The present study was performed to assess tumour-associated expression of the three TGF-beta isoforms in colon carcinoma. We report that colon carcinoma progression is associated with gradual and significant increases in expression of TGF-beta1 and TGF-beta2 mRNA and proteins. By contrast, TGF-beta3 expression was detected in normal colonic mucosa and, at slightly higher levels, in tumour tissues. In addition, plasma levels of both TGF-beta1 and TGF-beta2 were significantly higher in cancer patients when compared with unaffected individuals. Taken together, our results indicate distinct expression patterns of the three TGF-beta isoforms in colon carcinoma cells and possible systemic effects of TGF-beta1 and TGF-beta2 in tumour patients.Entities:
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Year: 2001 PMID： 11166150 DOI： 10.1016/s0959-8049(00)00391-9
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162