Literature DB >> 11166085

Symptom dimensions in recent-onset schizophrenia and mania: a principal components analysis of the 24-item Brief Psychiatric Rating Scale.

J Ventura1, K H Nuechterlein, K L Subotnik, D Gutkind, E A Gilbert.   

Abstract

Previous four- and five-factor solutions of the 18-item Brief Psychiatric Rating Scale (BPRS) suggested the possibility of an affective dimension in psychosis. A principal components analysis was used to analyze psychiatric symptom data rated on an expanded 24-item version of the BPRS. BPRS data were collected during a period of acute psychotic and affective illness with 114 young adult, recent-onset schizophrenia and schizoaffective patients and 27 bipolar manic patients. Principal components analyses of the 18-item and 24-item BPRS indicated a four-factor solution was the most interpretable. Principal components analysis of the 24-item BPRS produced a clear mania factor characterized by high loadings from items added to the 18-item BPRS, which included elevated mood, motor hyperactivity, and distractibility. This factor solution suggests that the 24-item BPRS allows for an expanded assessment of affective symptoms relating to a manic dimension. Potentially important symptoms that were added to the traditional 18-item version, namely suicidality, bizarre behavior, and self-neglect, also make clear contributions to other factors.

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Year:  2000        PMID: 11166085     DOI: 10.1016/s0165-1781(00)00228-6

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  111 in total

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7.  Hippocampal dysfunction during declarative memory encoding in schizophrenia and effects of genetic liability.

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8.  Negative symptoms and functioning during the first year after a recent onset of schizophrenia and 8 years later.

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9.  Further support for the role of dysfunctional attitudes in models of real-world functioning in schizophrenia.

Authors:  William P Horan; Yuri Rassovsky; Robert S Kern; Junghee Lee; Jonathan K Wynn; Michael F Green
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10.  Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task.

Authors:  Liberty S Hamilton; Lori L Altshuler; Jennifer Townsend; Susan Y Bookheimer; Owen R Phillips; Jeffrey Fischer; Roger P Woods; John C Mazziotta; Arthur W Toga; Keith H Nuechterlein; Katherine L Narr
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