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Literature DB >> 11165933

The role of fever in the infected host.

J D Hasday¹, K D Fairchild, C Shanholtz.

Abstract

Sepsis is a highly lethal clinical syndrome characterized by a systemic inflammatory response to infection. Fever, a non-specific acute-phase response, has been associated with improved survival and shortened disease duration in non-life-threatening infections. However, the influence of fever and the effects of antipyresis in patients with sepsis has not been prospectively studied in humans. This paper reviews the state of our knowledge concerning the biological effects of fever in infected hosts and the influence of fever and antipyretic therapy on survival during sepsis in experimental models and in man.

Entities: Disease Species

Mesh：

Substances：
Analgesics, Non-Narcotic

Year: 2000 PMID： 11165933 DOI： 10.1016/s1286-4579(00)01337-x

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

62 in total

1. Microbial growth inhibition by alternating electric fields in mice with Pseudomonas aeruginosa lung infection.

Authors: Moshe Giladi; Yaara Porat; Alexandra Blatt; Esther Shmueli; Yoram Wasserman; Eilon D Kirson; Yoram Palti
Journal: Antimicrob Agents Chemother Date: 2010-06-14 Impact factor: 5.191

Review 2. Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance.

Authors: Trupti D Vardam; Lei Zhou; Michelle M Appenheimer; Qing Chen; Wang-Chao Wang; Heinz Baumann; Sharon S Evans
Journal: Cytokine Date: 2007-07 Impact factor: 3.861

The role of fever in the infected host.

1. Microbial growth inhibition by alternating electric fields in mice with Pseudomonas aeruginosa lung infection.

Review 2. Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance.

Review 3. Primary immune surveillance: some like it hot.

4. Hypothermia and surgery: immunologic mechanisms for current practice.

5. Population-level effects of suppressing fever.

6. NICU admission hypothermia, chorioamnionitis, and cytokines.

7. Evolutionary psychiatry and depression: testing two hypotheses.

8. A role for the thermal environment in defining co-stimulation requirements for CD4(+) T cell activation.

9. Ability of Pharmacy Students, Pharmacists and Pharmacy Support Staff to Manage Childhood Fever via Simulation.

10. Acetaminophen has limited antipyretic activity in critically ill patients.