Literature DB >> 11165514

PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.

D A Okar1, A Manzano, A Navarro-Sabatè, L Riera, R Bartrons, A J Lange.   

Abstract

Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.

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Year:  2001        PMID： 11165514     DOI： 10.1016/s0968-0004(00)01699-6

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  93 in total

1.  An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase.

Authors:  Silvia Fernández de Mattos; Eric W-F Lam; Albert Tauler
Journal:  Biochem J       Date:  2002-11-15       Impact factor: 3.857

Review 2.  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.

Authors:  Mark H Rider; Luc Bertrand; Didier Vertommen; Paul A Michels; Guy G Rousseau; Louis Hue
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

3.  Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction.

Authors:  Jordi Rovira; Jose Maria Irimia; Mario Guerrero; Joan Aureli Cadefau; Roser Cussó
Journal:  Pflugers Arch       Date:  2012-01-13       Impact factor: 3.657

Review 4.  The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Authors:  Anthony R Cyr; Frederick E Domann
Journal:  Antioxid Redox Signal       Date:  2011-02-05       Impact factor: 8.401

5.  The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.

Authors:  Yan Tang; Hyokjoon Kwon; Brian A Neel; Michal Kasher-Meron; Jacob B Pessin; Eijiro Yamada; Jeffrey E Pessin
Journal:  J Biol Chem       Date:  2018-04-12       Impact factor: 5.157

Review 6.  Bifunctional xylanases and their potential use in biotechnology.

Authors:  Rakhee Khandeparker; Mondher Th Numan
Journal:  J Ind Microbiol Biotechnol       Date:  2008-03-26       Impact factor: 3.346

7.  Sequence-specific 1H, 13C and 15N resonance assignments of the rat liver fructose-2,6-bisphosphatase domain.

Authors:  Klaus Zangger; Konstantin Pervushin; Heinz Sterk; Alex J Lange; David A Okar
Journal:  J Biomol NMR       Date:  2003-11       Impact factor: 2.835

Review 8.  Stress eating and tuning out: cancer cells re-wire metabolism to counter stress.

Authors:  Zachary E Stine; Chi V Dang
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-10-07       Impact factor: 8.250

9.  Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.

Authors:  Qianwen Wang; Rajakumar V Donthi; Jianxun Wang; Alex J Lange; Lewis J Watson; Steven P Jones; Paul N Epstein
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-05-02       Impact factor: 4.733

10.  Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.

Authors:  Paul J Rozance; Amanda K Jones; Stephanie L Bourque; Angelo D'Alessandro; William W Hay; Laura D Brown; Stephanie R Wesolowski
Journal:  Am J Physiol Endocrinol Metab       Date:  2020-08-24       Impact factor: 4.310
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