Literature DB >> 11165171

Antibody libraries in drug and target discovery.

C Rader1.   

Abstract

Antibody libraries have come of age in the generation and evolution of monoclonal antibodies for therapeutic applications. Here, with an emphasis on cancer therapy, several examples are presented that illustrate the ability to design, engineer and select antibody libraries for different rationales in drug and target discovery.

Entities:  

Year:  2001        PMID： 11165171     DOI： 10.1016/s1359-6446(00)01595-6

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  7 in total

Review 1.  Mining human antibody repertoires.

Authors:  Roger R Beerli; Christoph Rader
Journal:  MAbs       Date:  2010-07-01       Impact factor: 5.857

2.  Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector.

Authors:  Thomas Hofer; Wisit Tangkeangsirisin; Michael G Kennedy; Rose G Mage; Stephen J Raiker; Karthik Venkatesh; Hakjoo Lee; Roman J Giger; Christoph Rader
Journal:  J Immunol Methods       Date:  2006-11-07       Impact factor: 2.303

3.  Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity.

Authors:  Ka Yin Kwong; Sivasubramanian Baskar; Hua Zhang; Crystal L Mackall; Christoph Rader
Journal:  J Mol Biol       Date:  2008-09-16       Impact factor: 5.469

4.  A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display.

Authors:  Sivasubramanian Baskar; Jessica M Suschak; Ivan Samija; Ramaprasad Srinivasan; Richard W Childs; Steven Z Pavletic; Michael R Bishop; Christoph Rader
Journal:  Blood       Date:  2009-08-10       Impact factor: 22.113

5.  Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

Authors:  Stephen J Stahl; Norman R Watts; Christoph Rader; Michael A DiMattia; Rose G Mage; Ira Palmer; Joshua D Kaufman; Jonathan M Grimes; David I Stuart; Alasdair C Steven; Paul T Wingfield
Journal:  J Mol Biol       Date:  2010-02-04       Impact factor: 5.469

Review 6.  From rabbit antibody repertoires to rabbit monoclonal antibodies.

Authors:  Justus Weber; Haiyong Peng; Christoph Rader
Journal:  Exp Mol Med       Date:  2017-03-24       Impact factor: 8.718

Review 7.  Rational monoclonal antibody development to emerging pathogens, biothreat agents and agents of foreign animal disease: The antigen scale.

Authors:  Jody D Berry
Journal:  Vet J       Date:  2005-09       Impact factor: 2.688
  7 in total

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