Literature DB >> 11165076

Preparation of redispersible dry emulsions by spray drying.

K L Christensen1, G P Pedersen, H G Kristensen.   

Abstract

Development of stable dry emulsions being able to reform the original o/w-emulsion by reconstitution in water is presented. Dry emulsions were prepared by spray drying liquid o/w-emulsions in a laboratory spray dryer. Three hydroxypropylmethylcellulose (HPMC) types were applied as solid carrier and emulsifier. The lipid phase was fractionated coconut oil. The ratio of solid carrier to lipid phase influenced the reconstitution properties. It was possible to prepare redispersible dry emulsions of a lipid content up to 40% dry powder mass. The different HPMC types had no noticeable effect on the reconstitution properties, but too viscous liquid o/w-emulsions were difficult to atomise. The type of rotary atomizer, or the rate of rotation did not affect the technical properties of the dry emulsions containing 40% lipid. It was concluded that low viscosity HPMC was a useful solid carrier. The dry emulsions remained physically stable for at least 6 months.

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Year:  2001        PMID: 11165076     DOI: 10.1016/s0378-5173(00)00596-2

Source DB:  PubMed          Journal:  Int J Pharm        ISSN: 0378-5173            Impact factor:   5.875


  7 in total

Review 1.  Transforming lipid-based oral drug delivery systems into solid dosage forms: an overview of solid carriers, physicochemical properties, and biopharmaceutical performance.

Authors:  Angel Tan; Shasha Rao; Clive A Prestidge
Journal:  Pharm Res       Date:  2013-06-18       Impact factor: 4.200

Review 2.  Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems.

Authors:  Tahnee J Dening; Shasha Rao; Nicky Thomas; Clive A Prestidge
Journal:  AAPS J       Date:  2015-09-09       Impact factor: 4.009

Review 3.  Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development.

Authors:  Deepa Nakmode; Valamla Bhavana; Pradip Thakor; Jitender Madan; Pankaj Kumar Singh; Shashi Bala Singh; Jessica M Rosenholm; Kuldeep K Bansal; Neelesh Kumar Mehra
Journal:  Pharmaceutics       Date:  2022-04-11       Impact factor: 6.525

4.  Novel spray-dried genipin-crosslinked casein nanoparticles for prolonged release of alfuzosin hydrochloride.

Authors:  Ahmed O Elzoghby; Wael M Samy; Nazik A Elgindy
Journal:  Pharm Res       Date:  2012-11-08       Impact factor: 4.200

5.  Formulation of re-dispersible dry o/w emulsions using cellulose nanocrystals decorated with metal/metal oxide nanoparticles.

Authors:  Tharwat I Shaheen; Isabelle Capron
Journal:  RSC Adv       Date:  2021-09-29       Impact factor: 4.036

6.  Influence of Polymer Modifiers on Selected Properties and Microstructure of Cement Waterproofing Mortars.

Authors:  Wacław Brachaczek; Adam Chleboś; Zbigniew Giergiczny
Journal:  Materials (Basel)       Date:  2021-12-09       Impact factor: 3.623

7.  Microencapsulation of fish oil using supercritical antisolvent process.

Authors:  Fahim Tamzeedul Karim; Kashif Ghafoor; Sahena Ferdosh; Fahad Al-Juhaimi; Eaqub Ali; Kamaruzzaman Bin Yunus; Mir Hoseini Hamed; Ashraful Islam; Mohammad Asif; Mohammed Zaidul Islam Sarker
Journal:  J Food Drug Anal       Date:  2017-02-14       Impact factor: 6.157

  7 in total

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