Literature DB >> 11163773

Aspirin promotes TFF2 gene activation in human gastric cancer cell lines.

P Azarschab1, E Al-Azzeh, W Kornberger, P Gött.   

Abstract

Trefoil factor family (TFF) peptides promote cell migration, heal the mucosa and may suppress tumor growth. In reporter gene assays we show that aspirin (1-12 mM) evokes a six-fold up-regulation of TFF2, but not TFF1 and TFF3 transcription in human gastrointestinal cell lines. 6 h after application up-regulation of endogenous TFF2 mRNA was observed. TFF2 transcription was enhanced by indomethacin and arachidonic acid but repressed by staurosporine, suggesting mediation via protein kinase C. We mapped an aspirin responding element -546 to -758 bp upstream of TFF2. Up-regulation of TFF2 by aspirin may partially explain the chemopreventive potential of low dose aspirin in gastrointestinal carcinogenesis.

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Year:  2001        PMID： 11163773     DOI： 10.1016/s0014-5793(00)02422-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells.

Authors:  E Al-azzeh; O Dittrich; J Vervoorts; N Blin; P Gött; B Lüscher
Journal:  Gut       Date:  2002-11       Impact factor: 23.059

Review 2.  Trefoil Factor Peptides and Gastrointestinal Function.

Authors:  Eitaro Aihara; Kristen A Engevik; Marshall H Montrose
Journal:  Annu Rev Physiol       Date:  2016-12-15       Impact factor: 19.318

3.  Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.

Authors:  Shu-Qing Shi; Jian-Ting Cai; Jian-Ming Yang
Journal:  World J Gastroenterol       Date:  2006-05-21       Impact factor: 5.742

4.  Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa.

Authors:  Guo-Yong Hu; Bao-Ping Yu; Wei-Guo Dong; Mu-Qi Li; Jie-Ping Yu; He-Sheng Luo; Zong-Xue Rang
Journal:  World J Gastroenterol       Date:  2003-05       Impact factor: 5.742

5.  Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing.

Authors:  C Hernández; E Santamatilde; K J McCreath; A M Cervera; I Díez; D Ortiz-Masiá; N Martínez; S Calatayud; J V Esplugues; M D Barrachina
Journal:  Br J Pharmacol       Date:  2008-12-09       Impact factor: 8.739

6.  Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland.

Authors:  Anna Margrét Halldórsdóttir; Margrét Sigurdardóttrir; Jón Gunnlaugur Jónasson; Margrét Oddsdóttir; Jónas Magnússon; Jeffrey R Lee; James R Goldenring
Journal:  Dig Dis Sci       Date:  2003-03       Impact factor: 3.199

7.  GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.

Authors:  Yoshimitsu Akiyama; Neil Watkins; Hiromu Suzuki; Kam-Wing Jair; Manon van Engeland; Manel Esteller; Hidekazu Sakai; Chun-Yan Ren; Yasuhito Yuasa; James G Herman; Stephen B Baylin
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

8.  Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro.

Authors:  Gi-Ho Sung; Hyun Chang; Ji-Yong Lee; Si Young Song; Han-Soo Kim
Journal:  Anim Cells Syst (Seoul)       Date:  2018-10-01       Impact factor: 1.815

9.  Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor.

Authors:  Abdelaziz Ghanemi; Mayumi Yoshioka; Jonny St-Amand
Journal:  Animals (Basel)       Date:  2020-09-14       Impact factor: 2.752
  9 in total

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