Literature DB >> 11163764

Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria.

D Ardail1, I Popa, K Alcantara, A Pons, J P Zanetta, P Louisot, L Thomas, J Portoukalian.   

Abstract

The free ceramide content of rat liver mitochondria was found to be 1.7 nmol/mg protein and outer membranes contained a three-fold higher concentration than inner membranes. The mitochondrial content in neutral glycolipids was 0.6 nmol/mg protein. The long-chain bases found in free ceramides were d18:1 sphingosine, d18:0 3-ketosphinganine and t21:1 phytosphingosine in increasing order. In contrast, 3-ketosphinganine was the only base of glucosylceramide and lactosylceramide of inner membranes, whereas d18:1 sphingosine was the major long-chain base of glucosylceramide of outer membranes.

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Year:  2001        PMID： 11163764     DOI： 10.1016/s0014-5793(00)02332-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

1.  A novel mitochondrial sphingomyelinase in zebrafish cells.

Authors:  Takeshi Yabu; Akio Shimuzu; Michiaki Yamashita
Journal:  J Biol Chem       Date:  2009-05-08       Impact factor: 5.157

Review 2.  Ceramide: second messenger or modulator of membrane structure and dynamics?

Authors:  Wim J van Blitterswijk; Arnold H van der Luit; Robert Jan Veldman; Marcel Verheij; Jannie Borst
Journal:  Biochem J       Date:  2003-01-15       Impact factor: 3.857

3.  Influence of Hydroxylation, Chain Length, and Chain Unsaturation on Bilayer Properties of Ceramides.

Authors:  Terhi Maula; Md Abdullah Al Sazzad; J Peter Slotte
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

4.  Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.

Authors:  Jeffrey S Monette; Luis A Gómez; Régis F Moreau; Brett A Bemer; Alan W Taylor; Tory M Hagen
Journal:  Biochem Biophys Res Commun       Date:  2010-06-25       Impact factor: 3.575

5.  Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.

Authors:  Sergei A Novgorodov; Bill X Wu; Tatyana I Gudz; Jacek Bielawski; Tatiana V Ovchinnikova; Yusuf A Hannun; Lina M Obeid
Journal:  J Biol Chem       Date:  2011-05-25       Impact factor: 5.157

Review 6.  The role of ceramides in metabolic disorders: when size and localization matters.

Authors:  Sarah M Turpin-Nolan; Jens C Brüning
Journal:  Nat Rev Endocrinol       Date:  2020-02-14       Impact factor: 43.330

7.  Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization.

Authors:  Vinodh Rajagopalan; Daniel Canals; Chiara Luberto; Justin Snider; Christina Voelkel-Johnson; Lina M Obeid; Yusuf A Hannun
Journal:  Biochim Biophys Acta       Date:  2014-12-04

8.  The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases.

Authors:  Dominique Ardail; Iuliana Popa; Jacques Bodennec; Pierre Louisot; Daniel Schmitt; Jacques Portoukalian
Journal:  Biochem J       Date:  2003-05-01       Impact factor: 3.857

9.  Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

Authors:  Clara Bionda; Jacques Portoukalian; Daniel Schmitt; Claire Rodriguez-Lafrasse; Dominique Ardail
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

10.  Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain.

Authors:  Hila Zigdon; Aviram Kogot-Levin; Joo-Won Park; Ruth Goldschmidt; Samuel Kelly; Alfred H Merrill; Avigdor Scherz; Yael Pewzner-Jung; Ann Saada; Anthony H Futerman
Journal:  J Biol Chem       Date:  2013-01-02       Impact factor: 5.157
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