| Literature DB >> 11163102 |
Y Iwase1, Y Takemura, M Ju-ichi, M Yano, C Ito, H Furukawa, T Mukainaka, M Kuchide, H Tokuda, H Nishino.
Abstract
Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter. HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.Entities:
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Year: 2001 PMID： 11163102 DOI： 10.1016/s0304-3835(00)00691-1
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679