| Literature DB >> 11162765 |
V V Yeremeev1, G R Stewart, O Neyrolles, K Skrabal, V G Avdienko, A S Apt, D B Young.
Abstract
Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model. Copyright 2000 Harcourt Publishers Ltd.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11162765 DOI： 10.1054/tuld.2000.0252
Source DB: PubMed Journal: Tuber Lung Dis ISSN： 0962-8479