Literature DB >> 11162721

Role of DNA adducts in hormonal carcinogenesis.

J G Liehr1.   

Abstract

In this review, a mechanism of estrogen-induced cancer has been examined which features a dual role of estrogen as hormone and carcinogen. Evidence exists that estrogens are metabolically activated to 4-hydroxylated metabolites by a specific cytochrome P450 in tissues prone to estrogen-induced cancer. These metabolites and their semiquinone/quinone oxidation products may cause various types of DNA damage. Preliminary data also exist that estrogens induce various genetic mutations. Tumors may develop from cells carrying such mutations and responding to receptor-mediated proliferation signals. Copyright 2000 Academic Press.

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Year:  2000        PMID： 11162721     DOI： 10.1006/rtph.2000.1432

Source DB:  PubMed          Journal:  Regul Toxicol Pharmacol        ISSN： 0273-2300            Impact factor:   3.271


  13 in total

1.  Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.

Authors:  Athena Starlard-Davenport; Yan Xiong; Stacie Bratton; Anna Gallus-Zawada; Moshe Finel; Anna Radominska-Pandya
Journal:  Steroids       Date:  2006-12-15       Impact factor: 2.668

Review 2.  A perspective on the role of estrogen in hormone-induced prostate carcinogenesis.

Authors:  Maarten C Bosland
Journal:  Cancer Lett       Date:  2012-08-29       Impact factor: 8.679

3.  Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?

Authors:  Judy L Bolton
Journal:  Curr Org Chem       Date:  2014-01-01       Impact factor: 2.180

4.  Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.

Authors:  Nelly Mauras; Richard J Santen; Gerardo Colón-Otero; Jobayer Hossain; Qingqing Wang; Clementina Mesaros; Ian A Blair
Journal:  J Clin Endocrinol Metab       Date:  2015-04-09       Impact factor: 5.958

5.  Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells.

Authors:  Karma C Fussell; Ronald G Udasin; Peter J S Smith; Michael A Gallo; Jeffrey D Laskin
Journal:  Carcinogenesis       Date:  2011-06-10       Impact factor: 4.944

6.  Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2.

Authors:  Karin Müller-Decker; Irina Berger; Karin Ackermann; Volker Ehemann; Svetlana Zoubova; Sebastian Aulmann; Walter Pyerin; Gerhard Fürstenberger
Journal:  Am J Pathol       Date:  2005-02       Impact factor: 4.307

7.  Sex steroids and prostate carcinogenesis: integrated, multifactorial working hypothesis.

Authors:  Maarten C Bosland
Journal:  Ann N Y Acad Sci       Date:  2006-11       Impact factor: 5.691

8.  Efficient synthesis, liquid chromatography purification, and tandem mass spectrometric characterization of estrogen-modified DNA bases.

Authors:  Qiang Zhang; Michael L Gross
Journal:  Chem Res Toxicol       Date:  2008-05-31       Impact factor: 3.739

9.  Balance of beneficial and deleterious health effects of quinones: a case study of the chemical properties of genistein and estrone quinones.

Authors:  Qiang Zhang; Tingting Tu; D André d'Avignon; Michael L Gross
Journal:  J Am Chem Soc       Date:  2009-01-28       Impact factor: 15.419

10.  Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.

Authors:  John F Reichard; Timothy P Dalton; Howard G Shertzer; Alvaro Puga
Journal:  Dose Response       Date:  2006-05-01       Impact factor: 2.658
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