| Literature DB >> 11162549 |
L A Duits1, M Rademaker, B Ravensbergen, M A van Sterkenburg, E van Strijen, P S Hiemstra, P H Nibbering.
Abstract
Intensive use of corticosteroids may be accompanied by increased susceptibility to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta-defensins (hBD), by cultured bronchial epithelial cells and mononuclear phagocytes. The results revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamethasone did not affect the (stimulated) mRNA expression of hBD-1 and hBD-2 by mononuclear phagocytes, whereas these cells did not express hBD-3 mRNA. Copyright 2001 Academic Press.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11162549 DOI： 10.1006/bbrc.2000.4157
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575