| Literature DB >> 11162436 |
F Marqués1, J L Moreau, G Peaucellier, J C Lozano, P Schatt, A Picard, I Callebaut, E Perret, A M Genevière.
Abstract
Kinases of the CDC2 family play a key role in cell cycle regulation and gene expression. In the present work, we identified sea urchin and human cDNAs encoding homologues of a high molecular mass CDC2-like kinase (designated CDC2L5) sharing respectively a PITAVRE and PITAIRE motif. The human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase, a previously published partial coding sequence. CDC2L5 overexpressed in mammalian cells is an approximately 170-kDa nuclear protein. The mRNA is present during the sea urchin early embryogenesis and is ubiquitously expressed in human tissues.Entities:
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Year: 2000 PMID： 11162436 DOI： 10.1006/bbrc.2000.4042
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575