| Literature DB >> 11161277 |
Philippe Biagini1, Pierre Gallian1, Houssam Attoui1, Mhammed Touinssi1, Jean-François Cantaloube1, Philippe de Micco2,1, Xavier de Lamballerie2.
Abstract
The phylogenetic relationship between the complete genomic sequences of ten Japanese and one French isolate of TT virus-like mini virus (TLMV) was investigated. Analysis of the variability of the nucleotide sequences and the detection of signature patterns for overlapping genes suggested that ORFs 1 and 2 are probably functional. However, this was not the case for a putative third ORF, ORF3. Throughout the viral genome, several nucleotide or amino acid motifs that are conserved in circoviruses such as TT virus (TTV) and chicken anaemia virus were identified. Phylogenetic analysis distinguished three main groups of TLMV and allowed the identification of putative recombination breakpoints in the untranslated region. TLMV genomes were detected by PCR in the plasma of 38/50 French blood donors tested and were also identified in peripheral blood mononuclear cells, faeces and saliva. A phylogenetic study of 37 TLMV strains originating from France, Japan and Brazil showed that groupings were not related to geographical origin.Entities:
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Year: 2001 PMID： 11161277 DOI： 10.1099/0022-1317-82-2-379
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891