| Literature DB >> 11161274 |
Tatsunori Nakano1,2, Ling Lu2, Xiaolei Hu2, Masashi Mizokami1, Etsuro Orito1, Craig N Shapiro2, Stephan C Hadler2, Betty H Robertson2.
Abstract
The complete genome sequences of hepatitis B virus (HBV) from 12 HBV-infected Yucpa Indians of Venezuela, a group with highly endemic HBV, were amplified and sequenced. The 12 isolates were closely related to each other, with 98.6-100% nucleotide identity. A phylogenetic tree based on the complete genome indicated clearly that they were genotype F. Three individuals had evidence of infection with two different HBV deletion mutants. In two individuals, a three amino acid deletion was identified just prior to the 'a' determinant loop of the S region. A third individual was infected with virus that contained a complete core reading frame and a population that contained a deletion in the middle of the core region. These results indicate that genotype F HBV is present in the Venezuelan Yucpa Amerindians and the complete genome sequence allowed the identification of two unique deletion mutants in a limited set of samples.Entities:
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Year: 2001 PMID： 11161274 DOI： 10.1099/0022-1317-82-2-359
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891