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Literature DB >> 111612

In vitro activity of HR 756, a new cephalosporin, against Neisseria gonorrhoeae.

Abstract

The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of >/=0.5 mug/ml for penicillin) and three beta-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 mug/ml and all inhibited by 0.25 mug/ml.

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Year: 1979 PMID： 111612 PMCID： PMC352682 DOI： 10.1128/AAC.15.3.452

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results.

Authors: H W Jaffe; J W Biddle; C Thornsberry; R E Johnson; R E Kaufman; G H Reynolds; P J Wiesner
Journal: N Engl J Med Date: 1976-01-01 Impact factor: 91.245

2. beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin.

Authors: K P Fu; H C Neu
Journal: Antimicrob Agents Chemother Date: 1978-09 Impact factor: 5.191

3. Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity.

Authors: H C Neu; K P Fu
Journal: Antimicrob Agents Chemother Date: 1978-04 Impact factor: 5.191

4. Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969.

Authors: J E Martin; A Lester; E V Price; J D Schmale
Journal: J Infect Dis Date: 1970-11 Impact factor: 5.226

5. Cefuroxime, a new cephalosporin antibiotic: activity in vitro.

Authors: C H O'Callaghan; R B Sykes; A Griffiths; J E Thornton
Journal: Antimicrob Agents Chemother Date: 1976-03 Impact factor: 5.191

6. Cefamandole: in vitro and clinical pharmacokinetics.

Authors: R S Griffith; H R Black; G L Brier; J D Wolny
Journal: Antimicrob Agents Chemother Date: 1976-11 Impact factor: 5.191

7. Patient variables associated with penicillin resistance in Neisseria gonorrhoeae.

Authors: C Thornsberry; H W Jaffe; G H Reynolds; A A Zaidi; P J Wiesner
Journal: Antimicrob Agents Chemother Date: 1978-09 Impact factor: 5.191

8. Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole.

Authors: S Eykyn; C Jenkins; A King; I Phillips
Journal: Antimicrob Agents Chemother Date: 1976-04 Impact factor: 5.191

9. National gonorrhea therapy monitoring study: treatment results.

Authors: R E Kaufman; R E Johnson; H W Jaffe; C Thornsberry; G H Reynolds; P J Wiesner
Journal: N Engl J Med Date: 1976-01-01 Impact factor: 91.245

10. Spectinomycin versus tetracycline for the treatment of gonorrhea.

Authors: W W Karney; A H Pedersen; M Nelson; H Adams; R T Pfeifer; K K Holmes
Journal: N Engl J Med Date: 1977-04-21 Impact factor: 91.245

14 in total

1. In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones.

Authors: B Christenson; J R Rodríguez; H F Gorbea; C H Ramírez-Rond
Journal: Antimicrob Agents Chemother Date: 1985-04 Impact factor: 5.191

2. In vitro susceptibility of 50 non-beta-lactamase-producing Neisseria gonorrhoeae strains to 12 antimicrobial agents.

Authors: J Rodríguez; Z Fuxench-Chiesa; C H Ramírez-Ronda; Y Kouri; R Cuevas; M Nevárez; M Pérez
Journal: Antimicrob Agents Chemother Date: 1983-02 Impact factor: 5.191

3. Competition of beta-lactam antibiotics for the penicillin-binding proteins of Neisseria gonorrhoeae.

Authors: T J Dougherty; A E Koller; A Tomasz
Journal: Antimicrob Agents Chemother Date: 1981-07 Impact factor: 5.191

Review 4. The third generation cephalosporins.

Authors: B Farber; R C Moellering
Journal: Bull N Y Acad Med Date: 1982-11

5. In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.

Authors: C N Baker; C Thornsberry; R N Jones
Journal: Antimicrob Agents Chemother Date: 1980-04 Impact factor: 5.191

6. HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.

Authors: V S Rajan; E H Sng; R Pang; N J Tan; T Thirumoorthy; K L Yeo
Journal: Br J Vener Dis Date: 1980-08