Literature DB >> 11160969

MRI measurement of brain iron in patients with restless legs syndrome.

R P Allen1, P B Barker, F W Wehrl, F Wehrl, H K Song, C J Earley.   

Abstract

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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Year:  2001        PMID： 11160969     DOI： 10.1212/wnl.56.2.263

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  115 in total

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